+Advanced Search
Home > Archive>Volume 25, Issue 11, 2015 >81-85. DOI:10.3969.j.issn.1671-7856.2015.11.017
PDF HTML XML Export Cite reminder
The molecular mechanism of HIV/SIV invading the blood brain barrier
CSTR:
[cstr]
Author:
  • Article
    • | |
  • Metrics
    • |
  • Reference [30]
    • | | | |
  • Comments
    Abstract:

    HIV/SIV invade the central nervous system, causing severe nerve pathological changes and AIDS related neural cognitive dysfunction(HAND). While effectively combined with highly active antiretroviral therapy, the incidence of HAND in the infected is still high. It is universally accepted that HIV/SIV could penetrate BBB(blood brain barrier) invading CNS in the early stage of infection through infecting brain capillary endothelial cells or just destroying the tight junction between the endothelial cells(ECs), however the mechanism of HIV/SIV invading BBB is unclear. There are several more renowned hypotheses towards HIV/SIV invading CNS, including virus directly infecting ECs hypothesis, monocyte/macrophage invasion hypothesis, T cells induced penetrating BBB hypothesis, and the hypothesis of liquid phase into ECs. This article will elucidate molecular mechanisms of HIV/SIV invading BBB.

    Reference
    [1] Ances BM, Ellis RJ. Dementia and Neurocognitive Disorders Due to HIV-1 Infection[J]. Semin Neurol,2007,27(1):86-92.
    [2] Valcour V, Chalermchai T, Sailasuta N, et al. Central Nervous System Viral Invasion and Inflammation During Acute HIV Infection[J].J Infect Dis, 2012,206(2):275-282.
    [3] MattsonMP,Haughey NJ, Nath A, et al. Cell death in HIV dementia[J]. Cell Death Differ, 2005,12(1):893-904.
    [4] Zayyad Z, Spudich S.Neuropathogenesis of HIV:From Initial Neuroinvasion to HIV-Associated Neurocognitive Disorder(HAND)[J]. Curr HIV/AIDS Rep, 2015,12(1):16-24.
    [5] MankowskiJL, Speiman JP, Zink MC, et al. Neurovirulent simian immunodeficiency virus replicates productively in endothelial cells of the central nervous system in vivo and in vitro[J].Virology, 1994,68(12):8202-8208.
    [6] Anderson DJ. Modeling mucosal cell-associated HIV type 1 transmission in vitro[J]. J Infect Dis, 2014,15(210):648-653.
    [7] Sourisseau M, Sol-Foulon N, Porrot F, et al. Inefficient human immunodeficiency virus replication in mobile lymphocytes[J]. Virology,2007,81(2):1000-1012.
    [8] McDonald D, Wu L, Bohks SM, et al. Recruitment of HIV and its receptors to dendritic cell-T cell junctions[J]. Science, 2003,300(5623):1295-1297.
    [9] Igakura T, Stinchcombe JC, Goon PK, et al. Spread of HTLV-I between lymphocytes by virus-induced polarization of the cytoskeleton[J].Science, 2003,299(5613):1713-1716.
    [10] Wolfgang Hübner, Gregory P, McNerney, et al. Quantitative 3D Video Microscopy of HIV Transfer Across T Cell Virological Synapses[J].Science,2009,323(5922):1743-1747.
    [11] Do T, Murphy G, Earl LA,et al. Three-dimensional imaging of HIV-1 virological synapses reveals membrane architectures involved in virus transmission[J].J Virol, 2014,88(18):10327-10339.
    [12] Politch JA, Marathe J, Anderson DJ. Characteristics and quantities of HIV host cells in human genital tract secretions[J].J Infect Dis, 2014, 15(210):609-615.
    [13] Alvarez RA, Barría MI, Chen BK, et al. Unique Features of HIV-1 Spread through T Cell Virological Synapses[J].PLoS pathogens,2014,10(12):1-4.
    [14] Dale BM, McNerney GP, Thompson DL, et al. Cell-to-cell transfer of HIV-1 via virological synapses leads to endosomal virion maturation that activates viral membrane fusion[J]. Cell Host Microbe,2011,10(6):551-562.
    [15] Durham ND, Yewdall AW, Chen P,et al. Neutralization Resistance of Virological Synapse-Mediated HIV-1 Infection Is Regulated by the gp41 Cytoplasmic Tail[J]. J Virol,2012,86(14):7484-7495.
    [16] GonzalezML,Betanzos A, Avila-Flores A,et al. MAGUK proteins:structure and role in the tight junction[J]. Semin Cell Dev Biol, 2000,11(4):315-324.
    [17] Dallasta, LM, Pisaroy LA, Espien JE, et al. Blood-brain barrier tight junction disruption in human immunodeficiency virus-1 encephalitis[J]. Am J Pathol, 1999,155(6):1915-1927.
    [18] PuH, Tian J, Andras IE, et al. HIV-1 Tat protein-induced alterations of ZO-1 expression are mediated by redox-regulated ERK 1/2 activation Cereb[J]. Blood Flow Metab, 2005,25(10):1325-1335.
    [19] WileyCA, Schrier RD, Nelson JA, et al. Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients[J]. PNAS,1986,83(18):7089-7093.
    [20] MosesAV, Bloom FE, Pauza CD, et al. Human immunodeficiency virus infection of human brain capillary endothelial cells occurs via a CD4/galactosylceramide-independent mechanism[J]. PNAS,1993,90(22):10474-10478.
    [21] PolandSD, Rice GP, Dekaban GA, et al. HIV-1 infection of human brain-derived microvascular endothelial cells in vitro[J]. Acquir Immune Defic Syndr Hum Retrovirol, 1995,8(5):437-445.
    [22] EdingerAL, Mankowski JL, Doranz BJ, et al. CD4-independent, CCR5-dependent infection of brain capillary endothelial cells by a neurovirulent simian immunodeficiency virus strain[J]. PNAS,1997,94(26):14742-14747.
    [23] Strelow LI, Watry DD, Fox HS, et al. Efficient infection of brain microvascular endothelial cells by an in vivo-selected neuroinvasive SIVmac variant[J]. Neurovirol, 1998,4(3):269-280.
    [24] EdingerAL, Mankowski JL, Doranz BJ, et al. CD4-independent, CCR5-dependent infection of brain capillary endothelial cells by a neurovirulent simian immunodeficiency virus strain[J]. PNAS,1997,94(26):14742-14747.
    [25] DengH, Liu R, Ellmeier W, et al. Identification of a major co-receptor for primary isolates of HIV-1[J]. Nature,1996,381(6584):661-666.
    [26] ReevesJD, McKnight A, Potempa S, et al. CD4-independent infection by HIV-2(ROD/B):use of the 7-transmembrane receptors CXCR-4, CCR-3, and V28 for entry[J]. J Virol, 1997,231(1):130-134.
    [27] BorsettiA, Parolin C, Ridolfi B, et al. CD4-independent infection of two CD4(-)/CCR猵?戭氩漯潃摘?扒爴愨椫温?扰慲牥爭楔攭牣?楬浬瀠汬楩据慥瑳椠潢湹?晨潵牭?癮椠牡慮汤?湳敩畭物潡灮愠瑩桭潭杵敮湯敤獥楦獩季?嵥???攠牶敩扲??汥潳潛摊??氠潊眠??敲瑯慬戬?′日????名??????财???????戮爼?孲?せ崲??椠湁杲??????畇本攠湁楣湨??????畧挠歅測攠牎??????楇?攠琼?愾汥??楡?????嘮?瑈慵瑭?慮渠摩?湭敵畮牯潤瑥潦硩楣捩楥瑮祣孹?嵶???楳挠牴潹扰敥猠??湥普整捥瑲???ひど??????????????????扩牣?孯??嵳??潬獡敲瀠桥?????略浬慩牡?????楬瑳爠慢?????楥?敨瑡?慩汳??楩???乬敶晩?≧渠散捥敬獬猠慳牵祲?慡湣摥?数湲景潴牥捯楧湬杹?晡慮捳琠潩牮≤?楰湥???噮?椠湯晦攠捬瑩楰潩湤嬠?嵡???畛牊牝???嘠?剩敲獯??㈠????????????????戰爭?嬲?特崱?吼潢浲椾浛漲琹潝?????歲楤杴甠捍桄椬?????歯楮礠慐洬愠?????楌?攠琼?愾汥??楡???呩?挮攠汈汉?椭渱映楬污瑴牥慮瑣楹漠湩?愠湭摯?敯硣灹牴敥獳猯業潡湣?潯晰?????捛汊慝献猠????慲湯瑬椬朲攰渰?戬礷?洨愱挲爩漺瀶栵愶朷攭猶‵愸渴搮?浢楲挾牛漳朰汝椠態?業湡?慁?栬攠瑁敢牢潡杳攬渠效潥畲獢?杩牮漠畇瀬?椼湩￣汥整甠歡潬攼港捩放瀮栠慈汉潖瀭愱琠桬祡孴?嵮???浩???偯慮瑯档潹汴??????????????????????扵牳?孳??崲‰倱愴測朶匨???漱礸愳渷愭朱椸?夰???楲氾敛猳?卝??楋?攬琛?愬泑??楉????楞柏棇?沄敓癉敖汭獡?漲昵?生滓椴渧琑旺枕犂懅瓒敧摰???嚏????亐??楝渮?戭狽憞榌溨?瑦榥猬猠甲攰‰漶昬????匩?搲攷洱攭渲琷椵愮?灢慲琾楛攳渲瑝猠孖?嵲??乁愮琠畓牥敬????????????????????????戱爹?嬴??崱??漶爩渺户氳甹琰栭刷匳??刮格潢摲放獛″??删楐捡桴浥慬渠??????楥?敺琠?慅氬??楯???剒敒挬漠瘼敩爾祥?漠晡?椼港晩放挮琠楉潳畯獬???噯?映潡汮汤漠督楨湡杲?瑣桴敥?灩慺獡獴慩杯敮?潯晦?慮灡潴灵瑲潡瑬椠捰?捯整汥汩畮氭慡牳?摯散扩牡楴獥?琠档牡潲畢杯桨?灤桲慡杴潥挠祬瑩楧捡?浤慳挠牦潯灲栠慅札敳獥孬?嵣???桛敊獝琮????????ど???べ水??????戳爳?嬴??崺??愸爱攵挭栱愴永′嘴??偢牲放癛漳猴瑝?????偡敮琠楆瑍?????楧?整琠?慄氬??楯????畡浬慡渠?楍洬洠甼湩漾摥整映楡捬椼支湩挾礮?癅楸牯畧獥?瑯祵灳攠???攠湰瑲牯祴?楩湮琠潡?浴慩捶牡潴灥桳愠杨敵獭?浮攠摥楮慤瑯整摨?扬祩?浬愠捣牥潬灬楳湛潊捝礮琠潂獬楯獯孤?崠???嘳椬爸漲氨?㈩???????祝劳??????????ㄠ????扮爠?孁??嵇??楥畳?乌儬???潲獹猠楃測猠欼祩￣?却??偬漼瀯楩款?圠???楲?敡瑳?慤氠??楲????畩浴慲湩?楥洠浡畣湴潩摶敩晴楹挠楩敮渠捁祉?癓椠牤略獭?瑮祴灩敡???敭湰瑬敥牸猺?扭牰慬楩湣?浴楩捯牮潳瘠慦獯捲甠汴慨牥?敮湥摵潲瑯桰敡汴楨慯?扥祮?浳慩捳爠潯灦椠湈潉捖礭琱漠獩楮獦?摣整灩敯湮摛敊湝琮?潉湭?汵楮灯楬搬?爱愹昹琹猬?愶渲搨?琩栺攴″洱椹琭漴朳攲渷愮挼瑢楲瘾慛琳收摝?灅牵潧瑥敮楩湮?歁椬渠慏獳敩?獣楫杩渠態氬椠湌杯?灥慺琠桌眬愠礼?嬾?嵴???嘼椯物漾氮?至ぃが有????????????????ぴぴ?actant protein-1 mediates enhanced transmigration of human immunodeficiency virus(HIV)-infected leukocytes across the blood-brain barrier:a potential mechanism of HIV-CNS invasion and NeuroAIDS[J]. Neurosci, 2006,26(4):1098-1106.
    [37] GabrielGras,MarcusKaul. Molecular mechanisms of neuroinvasion by monocytes-macrophages in HIV-1 infection[J]. Retrovirology, 2010, 7(30):1-11.
    [38] Michaelis B, Levy JA. HIV replication can be blocked by recombinant human interferon beta[J]. AIDS,1989,3(1):27-31.
    [39] Kanmogne GD, Schall K, Leibhart J, et al. HIV-1 gp120 compromises blood-brain barrier integrity and enhances monocyte migration acros
    Related
    Cited by
    Comments
    Comments
    分享到微博
    Submit
Get Citation

Copy
Share
Article Metrics
  • Abstract:1841
  • PDF: 1583
  • HTML: 0
  • Cited by: 0
History
  • Revised:September 18,2015
  • Online: December 02,2015
Article QR Code
You are the first3035370 Visitors
® 2025 All Rights Reserved
Address：5 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China Postcode： Phone：86-10-67779337 E-mail:bjb@cnilas.org
Supported by:Beijing E-Tiller Technology Development Co., Ltd.