Objective To investigate the effects of camel milk on body weight, blood glucose, lipid, insulin and PPAR-γ、TNF-α mRNA expressions in type 2 diabetes rats. Methods Type 2 diabetes was induced by high fat diet and small dose of STZ(i.g. 30 mg/kg), rats were divided into four groups, normal control(control) group, diabetes model(model) group, camel-low dose(CM-L) group(3.5 mg/kg·d), camel-high dose(CM-H) group(10 mg/kg·d). Body weight and fasting blood glucose were measured every week. Glucose tolerance test(OGTT) was conducted at 4th week. After 4 weeks administration, animals were decapitated, plasma lipid(TC、TG、HDL-C、LDL-C), insulin were assayed. The expression of PPAR-γ and TNF-α mRNA were measured using RT-PCR method. Results Compared with control group, the weight of model group lowered significantly(P < 0.01), FBG and blood glucose at 0、30、60、120 min of OGTT, as well as the TC, TG, LDL-C concentrations increased(P < 0.01), while HDL-C content reduced, and insulin level was higher than control rats. Compared with model group, body weight increased and blood glucose decreased in CM group, CM-H reduced the fasting glucose levels in 4th week and decreased the 30min glucose level significantly(P < 0.05). CM lowered the TC, TG, LDL-C, insulin and increased HDL-C concentration, and it is significantly in CM-H(P<0.05). There is a marked decrease in PPARγ mRNA expression(P < 0.05) and a significant increase in TNF-α mRNA expression(P < 0.01)in diabetes rats. Compared with model rats, PPARγ mRNA expression was ascended by CM administration, and it is notably in CM-H group(P < 0.05), while the TNF-α mRNA expression of diabetes rats was lower, but there is no significant. Conclusions CM can improve the lowered body weight, hyperglycosemia, abnormal glucose tolerance and dyslipidemia in type 2 diabetes. The mechanism of these maybe associated with the regulation of PPARγ and TNF-α mRNA.