P2X3 subunit was one of the P2X receptor family members, which highly selective expressd in the nociceptors, and involved in the pathological process of inflammatory pain. Currently, animal inflammatory pain models included formalin inflammatory pain model, Freund's adjuvant inflammatory pain model, the carrageenan inflammatory pain model, bee venom inflammatory pain model,et al.Different inflammatory pain model had different pathological features, the main features of the formalin pain model is double phase of spontaneous pain, due to different duration time of inflammation, carrageenan inflammatory pain model is commonly used in sub acute inflammation model, Freund's adjuvant inflammatory pain model, bee venom inflammatory pain model, and turpentine inflammatory pain model are for chronic inflammatory pain model research, the expression and function of P2X3 may be different.This paper focused on the effects of P2X3 receptors in different inflammatory pain models.