SONG Dan
Institute of Gene Engineered Animal Models for Human Diseases, Dalian Medical University, Dalian 116044, China;Institute of Integrative Medicine, Dalian Medical University, Dalian 116044, ChinaRAN Li-yuan
Institute of Gene Engineered Animal Models for Human Diseases, Dalian Medical University, Dalian 116044, ChinaJIANG Ru-jiao
Institute of Gene Engineered Animal Models for Human Diseases, Dalian Medical University, Dalian 116044, ChinaWU Ying-jie
Institute of Gene Engineered Animal Models for Human Diseases, Dalian Medical University, Dalian 116044, China;The Advanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China;Institute of Integrative Medicine, Dalian Medical University, Dalian 116044, ChinaIn spite of much progress on its mechanism, diagnosis and treatment, diabetes mellitus remains a public health challenge. The harm of diabetes is not significantly reduced, instead shows an increasing tendency year by year. To achieve an in-depth and comprehensive understanding of the underlying mechanism, and to develop efficacious, stable and hypoglycemia-risk free drugs, it is crucial to gain more knowledge about diabetes from animal models. In this review, the types of diabetes animal models, modeling methods, the advantages and disadvantages, their applicable scope are discussed aiming to provide a reference for researchers to choose appropriate animal models.
