Research progress of CYP450 genes expressed in brain involved in the metabolism of endogenous substances

doi:10.3969/j.issn.1671-7856.2018.01.020

Home > Archive>Volume 28, Issue 1, 2018 >113-117. DOI:10.3969/j.issn.1671-7856.2018.01.020

Research progress of CYP450 genes expressed in brain involved in the metabolism of endogenous substances
DOI:
                        10.3969/j.issn.1671-7856.2018.01.020
                    
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                        YANG XinlanYANG Xinlan
Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Center, Peking Union Medical College (PUMC); Key Laboratory of Human Diseases Comparative Medicine,National Health and Family Planning Commission (NHFPC) of P. R. C; Beijing 100021, China
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LV DanLV Dan
Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Center, Peking Union Medical College (PUMC); Key Laboratory of Human Diseases Comparative Medicine,National Health and Family Planning Commission (NHFPC) of P. R. C; Beijing 100021, China
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ZHANG LianfengZHANG Lianfeng
Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Center, Peking Union Medical College (PUMC); Key Laboratory of Human Diseases Comparative Medicine,National Health and Family Planning Commission (NHFPC) of P. R. C; Beijing 100021, China
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Affiliation:(Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Center, Peking Union Medical College (PUMC); Key Laboratory of Human Diseases Comparative Medicine,National Health and Family Planning Commission (NHFPC) of P. R. C; Beijing 100021, China)
Clc Number:R-33
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Abstract:

Cytochrome P450 (CYP450) is a superfamily of heme?thiolate proteins, which is involved in the metabolism and activation of various endogenous and exogenous substances, including food, drugs and pollutants. Previous studies of the CYP450 genes mainly focused on their function in drug metabolism. However, in recent years, studies have found that CYP450 are also involved in the development and progression of various diseases, including Parkinson’s disease (PD), cancer, cardiomyopathy and heart failure (HF). By far, the process and related mechanisms of CYP450 in the metabolism of endogenous substances in brain tissues has not been clarified yet. In this paper, we summarized the research progress of CYP450 genes involved in the metabolism of endogenous substances, in order to provide a new idea for the exploration of the functions of CYP450 genes expressed in the brain.

Key words:brain tissues; cytochrome P450; endogenous substances; metabolism

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Received:August 04,2017
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Online: February 02,2018
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