Object recognition test—a method to assess the learning and memory in mice based on their spontaneous behavior

doi:10.3969. j. issn. 1671 -7856. 2018. 03. 004

Home > Archive>Volume 28, Issue 3, 2018 >21-27. DOI:10.3969. j. issn. 1671 -7856. 2018. 03. 004

Object recognition test—a method to assess the learning and memory in mice based on their spontaneous behavior
DOI:
                        10.3969. j. issn. 1671 -7856. 2018. 03. 004
                    
CSTR:
                        [cstr]
                    
Author:
                        LYU Jingwei1LYU Jingwei
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China.
Find this author on All Journals
Find this author on BaiDu
Search for this author on this site
SONG Guangqing1SONG Guangqing
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China.
Find this author on All Journals
Find this author on BaiDu
Search for this author on this site
DONG Liming1DONG Liming
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China.
Find this author on All Journals
Find this author on BaiDu
Search for this author on this site
JIANG Ning1JIANG Ning
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China.
Find this author on All Journals
Find this author on BaiDu
Search for this author on this site
CHEN Shanguang2CHEN Shanguang
National Key Laboratory of Human Factors Engineering, China Astronaut Research and Training Center, Beijing 100094
Find this author on All Journals
Find this author on BaiDu
Search for this author on this site
LIU Xinmin1LIU Xinmin
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China.
Find this author on All Journals
Find this author on BaiDu
Search for this author on this site

                    
Affiliation:(1. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China. 2. National Key Laboratory of Human Factors Engineering, China Astronaut Research and Training Center, Beijing 100094)
Clc Number:R-33
Fund Project:

Article

Figures

Metrics

Reference

Cited by

Materials

Comments

Abstract:

Objective To develop a multi-mode, detailed and sensitive object recognition method for learning and memory research, including novel object recognition task, object location recognition task, temporal order memory task and object context recognition task in animals based on their spontaneous behavior. Methods Two strains of mice (KM and ICR) and four patterns were used to establish the object recognition method and several relative factors, such as time of test phase, delay between test phase and familiar phase were investigated. Results It was stable and reasonable to set the time of familiar phase as 5 min, the interval between test phase and familiar phase as 10 min, and the time of test phase as 3-5 min, under the precondition of habituation for three days and selecting the appropriate object pairs. Conclusions Object recognition test including four patterns has been systematically established as a stable, reliable and normative way for the research of animal learning and memory and drug development.

Key words:object recognition; object location; temporal order; object context; learning and memory; mice

Get Citation

Copy

Article Metrics

Abstract:1928
PDF: 1984
HTML: 0
Cited by: 0

History

Received:January 31,2018
Revised:
Adopted:
Online: April 11,2018
Published:

Home

About this journal

Editorial Board

Info for Author

Contact Us

中文版

Get Citation

Share

Article Metrics

History

Article QR Code