The structure of histone deacetylase 2 and its role in diseases

doi:10.3969/j. issn. 1671 -7856. 2018. 04. 021

Home > Archive>Volume 28, Issue 4, 2018 >116-119. DOI:10.3969/j. issn. 1671 -7856. 2018. 04. 021

The structure of histone deacetylase 2 and its role in diseases
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                        10.3969/j. issn. 1671 -7856. 2018. 04. 021
                    
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                        SUN XinSUN Xin
College of Veterinary Medicine,China Agricultural University National Animal Transmissible Spongiform Encephalopathy Laboratory,Beijing 100193,China
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ZHAO DemingZHAO Deming
College of Veterinary Medicine,China Agricultural University National Animal Transmissible Spongiform Encephalopathy Laboratory,Beijing 100193,China
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YANG LifengYANG Lifeng
College of Veterinary Medicine,China Agricultural University National Animal Transmissible Spongiform Encephalopathy Laboratory,Beijing 100193,China
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ZHOU XiangmeiZHOU Xiangmei
College of Veterinary Medicine,China Agricultural University National Animal Transmissible Spongiform Encephalopathy Laboratory,Beijing 100193,China
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Affiliation:(College of Veterinary Medicine,China Agricultural University National Animal Transmissible Spongiform Encephalopathy Laboratory,Beijing 100193,China)
Clc Number:R-33
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Abstract:

Histone acetylation is one of the most important reactions of post?translational modification of histones, which plays an important role in the regulation of epigenetic processes. Histone deacetylase 2 as a member of type I histone deacetylases, involved in the catalytic regulation of histone and a variety of non-histone deacetylation, regulates a variety of life processes. This paper summarizes the basic structure of histone deacetylase 2 and the role of histone deacetylase 2 in various diseases, and provides a theoretical basis for conducting related studies.

Key words:histone deacetylase 2; deacetylation; histone; transcriptional inhibition

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Received:September 20,2017
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Online: May 22,2018
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