Phagocytic function of microglia and underlying regulatory mechanism in neurodevelopment and neurodegenerative diseases

doi:10.3969/j. issn. 1671 -7856. 2018. 04. 022

Home > Archive>Volume 28, Issue 4, 2018 >120-126. DOI:10.3969/j. issn. 1671 -7856. 2018. 04. 022

Phagocytic function of microglia and underlying regulatory mechanism in neurodevelopment and neurodegenerative diseases
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                        10.3969/j. issn. 1671 -7856. 2018. 04. 022
                    
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                        LI Jingwen1LI Jingwen
Key Laboratory of Human Disease Comparative Medicine, National Health and Family Planning Commission of P. R. C, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Comparative Medicine Center, Peking Union Medical College, Beijing 100021,China
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ZHANG Li1ZHANG Li
Key Laboratory of Human Disease Comparative Medicine, National Health and Family Planning Commission of P. R. C, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Comparative Medicine Center, Peking Union Medical College, Beijing 100021,China
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ZHANG LianfengZHANG Lianfeng
1. Key Laboratory of Human Disease Comparative Medicine, National Health and Family Planning Commission of P. R. C, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Comparative Medicine Center, Peking Union Medical College, Beijing 100021,China. 2. Neuroscience Center, Chinese Academy of Medical Sciences, Beijing 100730
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Affiliation:(1. Key Laboratory of Human Disease Comparative Medicine, National Health and Family Planning Commission of P. R. C, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Comparative Medicine Center, Peking Union Medical College, Beijing 100021,China. 2. Neuroscience Center, Chinese Academy of Medical Sciences, Beijing 100730)
Clc Number:R-33
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Abstract:

Microglia, a type of neuroglia, has a variety of functions such as phagocytosis, clearance, antigen presentation, promotion of repairment of injury and secretion of extracellular signaling molecules, in which phagocytosis of microglia plays a crucial role in maintaining brain tissue, remodeling synapses, clearance of several aberrant proteins such as amyloid β in neurodegenerative diseases, and in neurodevelopment. This review briefly summarizes the phagocytic function of microglia with underlying regulatory mechanism in neurodevelopment and neurodegenerative diseases, aiming to provide a new thought for the therapy of neurodegenerative diseases.

Key words:microglia; phagocytosis; neurodevelopment; Aβ; neurodegenerative diseases

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Received:July 27,2017
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Online: May 22,2018
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