Application of three-dimensional cell culture in the study of Alzheimer’s disease

doi:10.3969/j. issn. 1671 -7856. 2018. 05. 003

Home > Archive>Volume 28, Issue 5, 2018 >12-15. DOI:10.3969/j. issn. 1671 -7856. 2018. 05. 003

Application of three-dimensional cell culture in the study of Alzheimer’s disease
DOI:
                        10.3969/j. issn. 1671 -7856. 2018. 05. 003
                    
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Author:
                        KANG MeimeiKANG Meimei
Department of Central Laboratory, Xuanwu Hospital, Capital Medical University; Beijing Geriatric Medical Research Center; Center of Alzheimer’s disease, Beijing Institute for Brain Disorders; Key Laboratory for Neurodegenerative Disease of Ministry of Education, Beijing 100053, China
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WANG RongWANG Rong
Department of Central Laboratory, Xuanwu Hospital, Capital Medical University; Beijing Geriatric Medical Research Center; Center of Alzheimer’s disease, Beijing Institute for Brain Disorders; Key Laboratory for Neurodegenerative Disease of Ministry of Education, Beijing 100053, China
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Affiliation:(Department of Central Laboratory, Xuanwu Hospital, Capital Medical University; Beijing Geriatric Medical Research Center; Center of Alzheimer’s disease, Beijing Institute for Brain Disorders; Key Laboratory for Neurodegenerative Disease of Ministry of Education, Beijing 100053, China)
Clc Number:R-33
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Abstract:

Cells in two-dimensional (2D) cultures gradually lose their original traits as they are passaged in vitro. Existing animal models are expensive and animal experiments require too much work to conduct large-scale experiments. Three-dimensional (3D) cell culture models have attracted increasing attention as they can circumvent the limitations of these previous two models. In 2014, it was reported that the incidence of Alzheimer’s disease (AD) in people over 65 years old was 5.14%. In China, the number of AD patients reached 8 million in 2016, but the pathogenesis of the disease is not yet clear. Study of AD is a ‘hot’ yet complicated issue. This article will briefly introduce 2D and 3D cell cultures and the application of 3D cell culture to AD research in recent years.

Key words:2D cell culture; 3D cell culture; Alzheimer’s disease

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Received:March 30,2018
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Online: June 26,2018
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