Research progress on animal models of Parkinson’s disease

doi:10.3969/j. issn. 1671 -7856. 2018. 05. 005

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Research progress on animal models of Parkinson’s disease
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                        10.3969/j. issn. 1671 -7856. 2018. 05. 005
                    
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                        ZHANG ZhichengZHANG Zhicheng
1. Kunming Medical University, Kunming 650500, China. 2. Center of Tree Shrews Germplasm Resource, Institute of Medical Biology, Chinese Academy of Medical Sciences/ Peking Union Medical College; Yunnan Key Laboratory of Major Infectious Diseases Vaccine Development, Kunming 650118
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YUAN Yuan2YUAN Yuan
Center of Tree Shrews Germplasm Resource, Institute of Medical Biology, Chinese Academy of Medical Sciences/ Peking Union Medical College; Yunnan Key Laboratory of Major Infectious Diseases Vaccine Development, Kunming 650118
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WANG Xuan2WANG Xuan
Center of Tree Shrews Germplasm Resource, Institute of Medical Biology, Chinese Academy of Medical Sciences/ Peking Union Medical College; Yunnan Key Laboratory of Major Infectious Diseases Vaccine Development, Kunming 650118
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SONG Qingkai2SONG Qingkai
Center of Tree Shrews Germplasm Resource, Institute of Medical Biology, Chinese Academy of Medical Sciences/ Peking Union Medical College; Yunnan Key Laboratory of Major Infectious Diseases Vaccine Development, Kunming 650118
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DAI Jiejie2DAI Jiejie
Center of Tree Shrews Germplasm Resource, Institute of Medical Biology, Chinese Academy of Medical Sciences/ Peking Union Medical College; Yunnan Key Laboratory of Major Infectious Diseases Vaccine Development, Kunming 650118
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Affiliation:(1. Kunming Medical University, Kunming 650500, China. 2. Center of Tree Shrews Germplasm Resource, Institute of Medical Biology, Chinese Academy of Medical Sciences/ Peking Union Medical College; Yunnan Key Laboratory of Major Infectious Diseases Vaccine Development, Kunming 650118)
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Abstract:

Parkinson’s disease (PD) is a progressive neurodegenerative disorder, with an etiology that is now considered to be due to interaction between genetic and environmental factors. Typical PD features include loss of dopaminergic neurons in the nigrostriatal region, with typical motor traits of PD associated with dopamine deficiency. Animal models have contributed to determining PD etiology and pathogenesis, as well as testing new therapeutic schedules and novel drug research. Rodents, tree shrews, primates, and other animal models of PD have been established by different method . These models each have their own advantages and limitations, showing different clinical features and pathological mechanisms to those in humans. Therefore, the appropriate model for scientific research must be carefully considered. This article reviews the main neurotoxic and transgenic models of PD.

Key words:Parkinson’ s disease, PD; 6-hydroxydopamine, 6-OHDA; 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine, MPTP; neurotoxins; transgenic; animal models

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Received:November 16,2017
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Online: June 26,2018
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