Effect of atrial natriuretic peptide (ANP) on pulmonary melanoma metastasis in ANP knockout mice and C57BL / 6J mice

doi:10.3969/j. issn. 1671 -7856. 2018. 06. 001

Home > Archive>Volume 28, Issue 6, 2018 >1-3. DOI:10.3969/j. issn. 1671 -7856. 2018. 06. 001

Effect of atrial natriuretic peptide (ANP) on pulmonary melanoma metastasis in ANP knockout mice and C57BL / 6J mice
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                        10.3969/j. issn. 1671 -7856. 2018. 06. 001
                    
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                        QI CuilingQI Cuiling
Vascular Biology Research Institute, School of Basic Course, Guangdong Pharmaceutical University, Guangzhou 510006, China
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CAO JinghuaCAO Jinghua
Vascular Biology Research Institute, School of Basic Course, Guangdong Pharmaceutical University, Guangzhou 510006, China
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HE YajunHE Yajun
Vascular Biology Research Institute, School of Basic Course, Guangdong Pharmaceutical University, Guangzhou 510006, China
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LI QianmingLI Qianming
Vascular Biology Research Institute, School of Basic Course, Guangdong Pharmaceutical University, Guangzhou 510006, China
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LI MengshiLI Mengshi
Vascular Biology Research Institute, School of Basic Course, Guangdong Pharmaceutical University, Guangzhou 510006, China
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YANG YangYANG Yang
Vascular Biology Research Institute, School of Basic Course, Guangdong Pharmaceutical University, Guangzhou 510006, China
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WANG LijingWANG Lijing
Vascular Biology Research Institute, School of Basic Course, Guangdong Pharmaceutical University, Guangzhou 510006, China
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Affiliation:(Vascular Biology Research Institute, School of Basic Course, Guangdong Pharmaceutical University, Guangzhou 510006, China)
Clc Number:R-33
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Abstract:

Objective To investigate the role of atrial natriuretic peptide (ANP) in lung metastasis of melanoma. Methods Melanoma B16F10 cells were intravenously injected into ANP knockout mice and C57BL/6J mice. After threeweeks, the mice were sacrificed, and the lungs were removed, embedded, and examined by pathology using HE staining. The numbers of metastatic foci on the lung surface and micrometastatic foci in the lung tissues were counted. Results The ANP knockout mice displayed fewer metastatic foci on the lung surface and less micrometastatic foci in the lung tissues of ANP knockout mice than in the C57BL/6J mice. Conclusions ANP deletion significantly suppresses the metastasis of melanoma in the lung of mice.

Key words:atrial natriuretic peptide, ANP; gene knockout mice; melanoma; lung metastasis

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Received:October 30,2017
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Online: July 20,2018
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