Research on the strategy of eradication of HIV latent reservoirs
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  • TONG Ling

    TONG Ling

    Comparative Medicine Center, Peking Union of Medical College (PUMC) & Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS). Key Laboratory of Human Diseases Comparative Medicine, National Health and Family Planning Commission of PRC. Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing 100021, China
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  • XUE Jing

    XUE Jing

    Comparative Medicine Center, Peking Union of Medical College (PUMC) & Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS). Key Laboratory of Human Diseases Comparative Medicine, National Health and Family Planning Commission of PRC. Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing 100021, China
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  • WEI Qiang

    WEI Qiang

    Comparative Medicine Center, Peking Union of Medical College (PUMC) & Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS). Key Laboratory of Human Diseases Comparative Medicine, National Health and Family Planning Commission of PRC. Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing 100021, China
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Affiliation:

(Comparative Medicine Center, Peking Union of Medical College (PUMC) & Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS). Key Laboratory of Human Diseases Comparative Medicine, National Health and Family Planning Commission of PRC. Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing 100021, China)

Clc Number:

R-33

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    Abstract:

    HIV latent reservoirs are the latent cells and tissues of HIV under the pressure of immune responses and antiviral therapy. Although HIV infection is effectively controlled by the advent of highly active antiretroviral therapy (HAART) and the viral load in the plasma is suppressed to a low level which are undetectable by most clinical measures, HAART is not able to completely eradicate the virus in the reservoirs. The viral rebound occurs when antiviral therapy is ceased. Therefore, the eradication of HIV reservoirs is a major challenge for the therapy of AIDS. In this paper, we will focus on the strategies of eradication of AIDS latent reservoirs.

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History
  • Received:November 15,2017
  • Online: July 20,2018
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