Research progress on chronic latent reactivation of primate cytomegalovirus⁃induced immune senescence

doi:10.3969/j. issn. 1671 -7856. 2018. 07. 022

Home > Archive>Volume 28, Issue 7, 2018 >124-128. DOI:10.3969/j. issn. 1671 -7856. 2018. 07. 022

Research progress on chronic latent reactivation of primate cytomegalovirus⁃induced immune senescence
DOI:
                        10.3969/j. issn. 1671 -7856. 2018. 07. 022
                    
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Author:
                        WANG YuhongWANG Yuhong
1. Department of Geriatric, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China. 2. National Clinical Research Center for Geriatric Disease, Chinese PLA General Hospital, Beijing 100039.
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QU GuangjinQU Guangjin
1. Department of Geriatric, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China. 2. National Clinical Research Center for Geriatric Disease, Chinese PLA General Hospital, Beijing 100039.
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XIAO Chong3XIAO Chong
Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS); Comparative Medicine Center, Peking Union Medical College (PUMC), Beijing 100021
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DENG Wei3DENG Wei
Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS); Comparative Medicine Center, Peking Union Medical College (PUMC), Beijing 100021
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Affiliation:(1. Department of Geriatric, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China. 2. National Clinical Research Center for Geriatric Disease, Chinese PLA General Hospital, Beijing 100039. 3. Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS); Comparative Medicine Center, Peking Union Medical College (PUMC), Beijing 100021)
Clc Number:R-33
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Abstract:

Reactivation of cytomegalovirus ( CMV) can induce T cells to undergo immune senescence, a mechanism of aging. After CMV infection of immunocompetent hosts, it persists in bone marrow. CMV is stimulated and propagates into circulation via differentiation?dependent reactivation throughout life. This article compares and reviews the immune status of human and nonhuman primates after CMV infection, the immune escape mechanisms, and the relationship with immune senescence. Such information may provide a basis for establishing models of immune senescence and the development of drugs and vaccines.

Key words:cytomegalovirus, CMV; immune senescence; comparative medicine; primates

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Received:February 02,2018
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Online: August 08,2018
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