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Home > Archive>Volume 28, Issue 9, 2018 >40-45. DOI:10.3969/j. issn. 1671 -7856. 2018. 09. 007
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Substance P in the digestive tract of a tree shrew cholesterol⁃induced gallstone model
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(1. Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650032, China. 2. Institute of Medical Biology, Chinese Academy of Medical Sciences, Kunming 650118. 3. Department of Experimental Animal, Kunming Medical University, Kunming 650500. 4. Clinical Skills Center, Kunming Medical University, Kunming 650500)

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R-33

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    Abstract:

    Objective To investigate the possibility of establishing the high?cholesterol forage?feeding tree shrew as a cholesterol?induced gallstone model and to determine the association of substance P (SP) with this model. Methods Upon establishment of the tree shrew cholesterol?induced gallstone model, the SP expression of the digestive tract was detected with immunohistochemistry method and compared among the model groups and the control group. Results In the model groups, immunohistochemistry showed that gastrointestinal SP expression was lower than that in the control group ( P < 0. 05). The tree shrew gallstone model was negatively correlated with SP expression level. Conclusions Tree shrew gallstones are associated with the regulation mechanisms of hormone secretion in the digestive tract.

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History
  • Received:January 17,2018
  • Online: October 08,2018
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