Research progress on conversion of fibroblasts into motor neurons

doi:10.3969/j. issn. 1671 -7856. 2018. 09. 020

Home > Archive>Volume 28, Issue 9, 2018 >110-114. DOI:10.3969/j. issn. 1671 -7856. 2018. 09. 020

Research progress on conversion of fibroblasts into motor neurons
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                        10.3969/j. issn. 1671 -7856. 2018. 09. 020
                    
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                        SHI Yuting1SHI Yuting
2013 undergraduate, major in Long?term?system Clinical Medicine (Paediatric Medicine), Capital Medical University; Beijing Children Hospital Affiliated to Capital Medical University, Beijing 100013, China.
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LI Feng2LI Feng
Neurobiology Department of Capital Medical University; Beijing Institute for Brain Disorders; Beijing Center of Neural Regeneration and Repair, Beijing 100069
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Affiliation:(1. 2013 undergraduate, major in Long⁃term⁃system Clinical Medicine (Paediatric Medicine), Capital Medical University; Beijing Children Hospital Affiliated to Capital Medical University, Beijing 100013, China. 2. Neurobiology Department of Capital Medical University; Beijing Institute for Brain Disorders; Beijing Center of Neural Regeneration and Repair, Beijing 100069)
Clc Number:R-33
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Abstract:

There is currently no effective treatment for some motor neuron diseases, such as spinal muscular atrophy and amyotrophic lateral sclerosis. With the development of induced pluripotent stem cells and cell reprogramming technology, it is possible to induce the production of motor neurons from a patient’s somatic cells in vitro for autologous transplantation. The differentiated motor neurons can also be used as cell models for studying disease mechanisms and for drug screening. Many researchers are now focusing on the differentiation of motor neurons from fibroblasts in vitro; here, we summarize three different methods for this, namely, differentiation through induced pluripotent stem cells, neural stem cells, and direct conversion.

Key words:motor neuron; fibroblast; differentiation; cell reprogramming; induced pluripotent stem cell

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Received:December 18,2017
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Online: October 08,2018
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