The stellate ganglion (SG) is functionally a sympathetic ganglion. Stellate ganglion block (SGB) refers to a variety of methods for sympathetic blockade of the head, face, neck, upper limbs, and upper chest, which are innervated by stellate ganglia. SGB has been demonstrated to produce therapeutic or protective effects in multiple systems throughout the body, but the exact mechanism involved has not yet been elucidated. Rat SG resembles the anatomy and function of the equivalent system in human, so rat is an ideal model for mimicking human SGB and can provide a basis for researching the molecular biological mechanism behind the effects of SGB. At present, the methods of rat SGB have rarely been described and mostly have been simply mentioned as part of the experimental operation, and there is no literature to summarize the approaches used. Therefore, the method for establishing the rat SGB model is reviewed here.