Chemotherapy-induced diarrhea is a common toxic side reaction of chemotherapy; The pathogenesis of CID has not been fully elucidated; and research cannot be carried out directly in humans; Therefore; it is necessary to establish related animal models; In this study; we searched literature databases; summarized the existing methods of model construction; and reviewed the various models of CID; including tumor-bearing; non-tumor-bearing; and gene knockout models; to provide a reference for the research and prevention of CID.