Current status of the research on induced neural differentiation of adipose-derived stem cells

doi:10.3969/j. issn. 1671 -7856. 2019. 02. 018

Home > Archive>Volume 29, Issue 2, 2019 >106-110. DOI:10.3969/j. issn. 1671 -7856. 2019. 02. 018

Current status of the research on induced neural differentiation of adipose-derived stem cells
DOI:
                        10.3969/j. issn. 1671 -7856. 2019. 02. 018
                    
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                        LI KeyaLI Keya
Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS); Comparative Medicine Center, Peking Union Medical College (PUMC); Key Laboratory of Human Disease Comparative Medicine,National Health Commission of the People’s Republic of China; Beijing 100021, China
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BAI LinBAI Lin
Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS); Comparative Medicine Center, Peking Union Medical College (PUMC); Key Laboratory of Human Disease Comparative Medicine,National Health Commission of the People’s Republic of China; Beijing 100021, China
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GAO ShupingGAO Shuping
Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS); Comparative Medicine Center, Peking Union Medical College (PUMC); Key Laboratory of Human Disease Comparative Medicine,National Health Commission of the People’s Republic of China; Beijing 100021, China
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QIN ChuanQIN Chuan
Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS); Comparative Medicine Center, Peking Union Medical College (PUMC); Key Laboratory of Human Disease Comparative Medicine,National Health Commission of the People’s Republic of China; Beijing 100021, China
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Affiliation:(Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS); Comparative Medicine Center, Peking Union Medical College (PUMC); Key Laboratory of Human Disease Comparative Medicine,National Health Commission of the People’s Republic of China; Beijing 100021, China)
Clc Number:R-33
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Abstract:

Neurodegenerative diseases are common conditions globally that involve the degeneration of neurons, for which no effective curative measures are available. Stem cells have the potential to undergo self-renewal and directional differentiation, potentially providing new therapeutic method for the recovery of brain function in neurodegenerative diseases. In recent years, with the development of stem cell biology, it has been found that adipose stem cells are pluripotent stem cells that develop from the middle germ layer, which can differentiate into different lineages upon exposure to specific growth factors and environmental conditions.They have the benefits of being easily accessible to researchers and simple to culture. Therefore, adipose tissue-derived stem cells have unique advantages in treating neurodegenerative diseases. This article provides an overview of neurodegenerative diseases, the biological characteristics of adipose-derived stem cells, and the conditions for differentiating them into the components of neural systems.

Key words:adipose-derived stem cell; neurodegenerative disease; differentiation

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Received:July 29,2018
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Online: March 14,2019
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