Recent progress in research on the expression and effects of HOXA11-AS in malignant tumors
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(Department of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University,Harbin 150086, China)

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R-33

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    Abstract:

    The long noncoding RNA HOXA11 antisense RNA (HOXA11-AS) was recently discovered in a mouse embryo cDNA library using the probe from the sense HOXA11 cDNA sequence. Since then, it has been found to play important roles in human cervical cancer, gastric cancer, and gliomas. HOXA11-AS can promote tumor malignancy (i.e.,proliferation and metastasis) by interacting with various miRNAs and proteins such as EZH2, providing new potential routes for the potential treatment of cancers.

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History
  • Received:August 02,2018
  • Online: March 14,2019
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