Progress in research on lysosome and pathophysiology of intrinsic renal cells

doi:10.3969/j. issn. 1671 -7856. 2019. 02. 021

Home > Archive>Volume 29, Issue 2, 2019 >124-127. DOI:10.3969/j. issn. 1671 -7856. 2019. 02. 021

Progress in research on lysosome and pathophysiology of intrinsic renal cells
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                        10.3969/j. issn. 1671 -7856. 2019. 02. 021
                    
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                        ZOU TingZOU Ting
Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001,China
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WANG ShujunWANG Shujun
Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001,China
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TANG HaoxuanTANG Haoxuan
Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001,China
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YANG ChenYANG Chen
Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001,China
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PAN QingjunPAN Qingjun
Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001,China
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LIU HuafengLIU Huafeng
Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001,China
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Affiliation:(Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001,China)
Clc Number:R-33
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Abstract:

The lysosome, an organelle rich in acidic hydrolase, is the main degradation organelle in the cell and is involved in cell processes such as secretion, plasma membrane repair, cell signaling, and energy metabolism. Lysosomal dysfunction may be related to the development of various diseases. In recent years, studies have shown that lysosomal dysfunction may be involved in the development of chronic kidney disease(CKD): lysosomal dysfunction of podocytes interrupts autophagy, inducing transdifferentiation and damage of podocytes. Lysosomal damage mediates apoptosis in proximal tubule epithelial cells via oxidative stress. Lysosomal damage leads to reduced degradation of type I collagen in mesangial cells. Renal endothelial cell dysfunction is closely related to the abnormal expression of lysosomal cathepsin-S and α-galactosidase-A. In summary, lysosomal dysfunction is closely linked to the pathology of intrinsic renal cells. Elucidation of the function of the lysosome in intrinsic renal cells should provide new ideas for clarifying the mechanism of intrinsic renal cell damage in chronic kidney disease.

Key words:lysosome; podocyte; proximal tubular epithelial cell; mesangial cell; endothelial cell; pathophysiology

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Received:August 07,2018
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Online: March 14,2019
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