Objective To observe the effects of treatment with Guizhi Fuling decoction on human endometrialcarcinoma HEC-1-B cancer in unde mouse models. Methods HEC-1-B cancer model nude mice were divided into threegroups. The model group received intragastric gavage of deionized water, the Guizhi Fuling decoction group receivedintragastric gavage of 2. 4 g/ kg Guizhi Fuling decoction, and the carboplatin injection group received a single intraperitonealinjection of 20 mg/ kg carboplatin. Results Both Guizhi Fuling decoction and carboplatin injection significantly reducedthe HEC-1-B tumor volume ( P <0. 05). Guizhi Fuling decoction promoted the expression of caspase-3 and reduced the expression of Bcl-2 protein. Conclusions Guizhi Fuling decoction has inhibitory effects on endometrial cancer.