Advances in experimental studies of the treatment of diabetic nephropathy with traditional Chinese medicine alkaloids

doi:10.3969/j. issn. 1671 -7856. 2019. 03. 021

Home > Archive>Volume 29, Issue 3, 2019 >117-122. DOI:10.3969/j. issn. 1671 -7856. 2019. 03. 021

Advances in experimental studies of the treatment of diabetic nephropathy with traditional Chinese medicine alkaloids
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                        10.3969/j. issn. 1671 -7856. 2019. 03. 021
                    
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                        ZHAO Long1ZHAO Long
Undergraduate of Medical College of Yan’an University, Yan’an 716000, China.
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JI Jinshan2JI Jinshan
Department of Preventive Medicine, Medical College of Yan’an University, Yan’an 716000.
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LI Baoli3LI Baoli
Department of Pharmacology, Medical College of Yan’an University, Yan’an 716000
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CAO Jing1CAO Jing
Undergraduate of Medical College of Yan’an University, Yan’an 716000, China.
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DENG Feilong1DENG Feilong
Undergraduate of Medical College of Yan’an University, Yan’an 716000, China.
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XI Liao1XI Liao
Undergraduate of Medical College of Yan’an University, Yan’an 716000, China.
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ZHANG Xin1ZHANG Xin
Undergraduate of Medical College of Yan’an University, Yan’an 716000, China.
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Affiliation:(1. Undergraduate of Medical College of Yan’an University, Yan’an 716000, China.2. Department of Preventive Medicine, Medical College of Yan’an University, Yan’an 716000.3. Department of Pharmacology, Medical College of Yan’an University, Yan’an 716000)
Clc Number:R-33
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Abstract:

Alkaloids are a class of nitrogen-containing alkaloids, which have many physiological activities, such asanti-tumor, and hypoglycemic effects. At present, the main alkaloids that can alleviate or delay the process of diabeticnephropathy in experimental animals include pyridine derivatives, pyrrolidine derivatives, scopolamine derivatives,isoquinoline derivatives, pyridine derivatives, isoquinoline derivatives, pyrazine derivatives, organic amines, and terpenealkaloids. Common alkaloids are berberine, ligustrazine, anisodamine, betaine, matrine, and colchicine, among others.Alkaloids have a variety of mechanisms for renal protection, including regulating oxidative stress, improving insulin resistance, reducing the infiltration of inflammatory factors, and downregulating or increasing the expression of related factors.

Key words:diabetic nephropathy; alkaloid compound; traditional Chinese medicine

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Received:September 14,2018
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Online: April 10,2019
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