Research progress on the Graves’ disease susceptibility genes
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(1. Department of Immunology, Special Key Laboratory of Gene Detection and Therapy of Guizhou Province, Zunyi Medical University, Zunyi 563000, China. 2. Department of Basic Medical Education, Zunyi Medical University, Zunyi 563000)

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R-33

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    Abstract:

    Graves’ disease (GD), the most common clinical type of hyperthyroidism, is a common organ-specificautoimmune disease. Although its etiology involves genetic and environmental factors, the exact pathogenesis of GD remainsunclear. Extensive genome-wide association studies ( GWAS) have identified various genes that contribute to thedevelopment of GD. This article reviews progress in our identification of susceptibility genes for GD, and provides a preliminary discussion on the genetic mechanism that promote GD onset.

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History
  • Received:December 03,2018
  • Online: May 10,2019
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