A comparative study of animal model selection and preparation for knee osteoarthritis

doi:10.3969/j. issn. 1671 -7856. 2019. 05. 020

Home > Archive>Volume 29, Issue 5, 2019 >125-130. DOI:10.3969/j. issn. 1671 -7856. 2019. 05. 020

A comparative study of animal model selection and preparation for knee osteoarthritis
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                        10.3969/j. issn. 1671 -7856. 2019. 05. 020
                    
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                        WU Qiang1WU Qiang
Acupuncture and Tuina College/3rd Affiliated Hospital, Chengdu University of TCM, Chengdu 610075, China.
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ZHENG Qianhua1ZHENG Qianhua
Acupuncture and Tuina College/3rd Affiliated Hospital, Chengdu University of TCM, Chengdu 610075, China.
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JIANG Yilu1JIANG Yilu
Acupuncture and Tuina College/3rd Affiliated Hospital, Chengdu University of TCM, Chengdu 610075, China.
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REN Runyuan2REN Runyuan
Basic Medical College, Chengdu University of TCM, Chengdu 610075.
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LI Ying3LI Ying
Graduate Department,Chengdu University of TCM, Chengdu 610075
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Affiliation:(1. Acupuncture and Tuina College/3rd Affiliated Hospital, Chengdu University of TCM, Chengdu 610075, China.2. Basic Medical College, Chengdu University of TCM, Chengdu 610075. 3. Graduate Department,Chengdu University of TCM, Chengdu 610075)
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Abstract:

Knee osteoarthritis (KOA) is a degenerative and intractable disease with high morbidity. Animal modelsof KOA provide an effective tool for studying the disease pathogenesis, potential treatments and their mechanism of action.A variety of animal models currently exist for studies of KOA, each with its own characteristics and advantages. In additionto the author’s own research on animal models of this disease, this article reviews the literature on method ologies forestablishing animal models of KOA. This article explores the selection criteria and method of preparing experimental KOAanimal models, in order to provide an effective reference for researchers who wish to apply these models to their own work.

Key words:osteoarthritis; animal model; experimental study

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Received:December 24,2018
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Online: June 05,2019
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