Difference in changes of peripheral blood and immune cell phenotypes between aged and young C57BL / 6J mice

doi:10.3969/j. issn. 1671 -7856. 2019. 07. 004

Home > Archive>Volume 29, Issue 7, 2019 >24-28. DOI:10.3969/j. issn. 1671 -7856. 2019. 07. 004

Difference in changes of peripheral blood and immune cell phenotypes between aged and young C57BL / 6J mice
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                        10.3969/j. issn. 1671 -7856. 2019. 07. 004
                    
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                        GUAN Bowen1GUAN Bowen
Institute of Laboratory Animal Sciences,Chinese Academy of Medical Sciences; Comparative Medicine Center,Peking Union Medical College; NHC Key Laboratory of Human Disease Comparative Medicine; Beijing Engineering Research Center for Laboratory Animal Models of Human Critical Diseases, Beijing 100021,China.
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LU Yanhua1LU Yanhua
Institute of Laboratory Animal Sciences,Chinese Academy of Medical Sciences; Comparative Medicine Center,Peking Union Medical College; NHC Key Laboratory of Human Disease Comparative Medicine; Beijing Engineering Research Center for Laboratory Animal Models of Human Critical Diseases, Beijing 100021,China.
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SU Lulu1SU Lulu
Institute of Laboratory Animal Sciences,Chinese Academy of Medical Sciences; Comparative Medicine Center,Peking Union Medical College; NHC Key Laboratory of Human Disease Comparative Medicine; Beijing Engineering Research Center for Laboratory Animal Models of Human Critical Diseases, Beijing 100021,China.
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WANG Yuquan1WANG Yuquan
Institute of Laboratory Animal Sciences,Chinese Academy of Medical Sciences; Comparative Medicine Center,Peking Union Medical College; NHC Key Laboratory of Human Disease Comparative Medicine; Beijing Engineering Research Center for Laboratory Animal Models of Human Critical Diseases, Beijing 100021,China.
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LI Deguan2LI Deguan
Institute of Radiation Medicine,Chinese Academy of Medical Sciences and Peking Union Medical College;Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine,Tianjin 300192
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MENG Aimin1MENG Aimin
Institute of Laboratory Animal Sciences,Chinese Academy of Medical Sciences; Comparative Medicine Center,Peking Union Medical College; NHC Key Laboratory of Human Disease Comparative Medicine; Beijing Engineering Research Center for Laboratory Animal Models of Human Critical Diseases, Beijing 100021,China
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Affiliation:(1. Institute of Laboratory Animal Sciences,Chinese Academy of Medical Sciences; Comparative Medicine Center,Peking Union Medical College; NHC Key Laboratory of Human Disease Comparative Medicine; Beijing Engineering Research Center for Laboratory Animal Models of Human Critical Diseases, Beijing 100021,China.2. Institute of Radiation Medicine,Chinese Academy of Medical Sciences and Peking Union Medical College;Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine,Tianjin 300192)
Clc Number:R-33
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Abstract:

Objective To investigate the changes of peripheral blood and immune cell phenotypes between agedand young C57BL/6J mice. Methods Peripheral blood cell count, immune organ coefficient and peripheral blood immunecell phenotype in aged C57BL/6J mice (19 months) and 2-month-old C57BL/6J mice used as control adult mice wereanalyzed. Results Compared with young mice, the aged mice had an increased peripheral blood platelet count, increasedproportion of neutrophils, and a decreased proportion of lymphocytes ( P <0. 001). The thymus coefficient was significantlyreduced ( P <0. 001). The percentage of CD4+ cells in the peripheral blood immune cell typing was obviously reduced ( P <0. 001). Conclusions The blood cells in aged mice are differentially skewed, and helper T-cell numbers declined. Thechanges are similar to those in the aging human. This study provides basic data for research on immuno-senescence.

Key words:C57BL/6J mouse; peripheral blood cell count; immune organ coefficient; peripheral blood immune typing

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Received:February 19,2019
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Online: August 01,2019
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