Objective To investigate the difference between BALB/ c mutant curly mice and control BALB/ cmice in terms of natural healing of skin injuries. Methods Ten 6-week-old BALB/ c mutant curly mice and 10 controlBALB/ c mice were selected. Two full-thickness skin wounds with a diameter of 0. 5 cm were created on the back of themice. A skin injury model was used. Skin healing was observed at 3, 7, 10, and 14 days after injury, and changes in theskin damage area and the wound healing rate were measured. Animals were sacrificed at 3, 7, 10, and 14 days after injury.HE staining and Sirius staining were performed to observe pathological changes in the skin during healing. Results Theskin wounds healed faster in the mutant curly mice at 3 and 7 days after wound healing. The skin wound healing rate of thecurly mice at 3 and 7 days after injury was significantly higher than that of the control mice ( P < 0. 05), but there was nosignificant difference between the two groups at 10 and 14 days after injury. The pathological examination showed that thecollagen fibers of the mutant curly haired mice increased significantly 3 days after injury, and there was a small amount ofinflammatory cell infiltration, and capillary dilation and congestion. Collagen grew rapidly 7 days after injury, levels ofgranulation tissue increased significantly, and some epidermis regenerated and grew. The Sirius scarlet staining resultshowed that collagen fibers and granulation tissue were present from the bottom layer of the injury, to repair the damagedarea, until the epidermis and hair follicles grew out from 3 to 14 days in the curly-haired mice. Conclusions BALB/ cmutant curly mice have better healing ability than control mice in the early stage of skin trauma, which provides a theoretical reference for the application of BALB/ c mutant mice in skin wound healing models in the future.