Research progress on the role of autophagy inhibitor, 3-methyladenine, in nervous system diseases

doi:10.3969/j. issn. 1671 -7856. 2019. 08. 021

Home > Archive>Volume 29, Issue 8, 2019 >129-134. DOI:10.3969/j. issn. 1671 -7856. 2019. 08. 021

Research progress on the role of autophagy inhibitor, 3-methyladenine, in nervous system diseases
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                        10.3969/j. issn. 1671 -7856. 2019. 08. 021
                    
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                        FENG XiumeiFENG Xiumei
College of Acupuncture-Moxibustion and Massage, Chengdu University of Traditional Chinese Medicine,Chengdu 610075, China
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XU MingminXU Mingmin
College of Acupuncture-Moxibustion and Massage, Chengdu University of Traditional Chinese Medicine,Chengdu 610075, China
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HUANG ChenHUANG Chen
College of Acupuncture-Moxibustion and Massage, Chengdu University of Traditional Chinese Medicine,Chengdu 610075, China
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LI YingLI Ying
College of Acupuncture-Moxibustion and Massage, Chengdu University of Traditional Chinese Medicine,Chengdu 610075, China
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ZHANG WeiZHANG Wei
College of Acupuncture-Moxibustion and Massage, Chengdu University of Traditional Chinese Medicine,Chengdu 610075, China
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Affiliation:(College of Acupuncture-Moxibustion and Massage, Chengdu University of Traditional Chinese Medicine,Chengdu 610075, China)
Clc Number:R-33
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Abstract:

3-methyladenine (3-MA) is a classic autophagy inhibitor that mainly inhibits autophagosome formationand development. In the nervous system, 3-MA plays an important role in central nervous system diseases, peripheralnervous system diseases, nerve injuries, and neurodegenerative diseases. However, the exact effect of 3-MA in nervoussystem diseases is controversial, and its application lacks systematic discussion. This paper reviews both the role of 3-MA innervous system diseases and the relevant research on this role, and to provide new ideas for further research.

Key words:3-methyladenine; autophagy; nervous system diseases; research progress

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Received:January 25,2019
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Online: September 12,2019
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