Research progress of Parkinson’s disease models based on α-synuclein fibrils

doi:10.3969/j. issn. 1671 -7856. 2019. 09. 016

Home > Archive>Volume 29, Issue 9, 2019 >103-108. DOI:10.3969/j. issn. 1671 -7856. 2019. 09. 016

Research progress of Parkinson’s disease models based on α-synuclein fibrils
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                        10.3969/j. issn. 1671 -7856. 2019. 09. 016
                    
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                        LUO Haiyu1LUO Haiyu
Center for Drug Safety Evaluation and Research, Institute of Medical Biology, Chinese Academy of Medical Sciences &Peking Union Medical College, Kunming 650118, China.
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WU Zhengcun1WU Zhengcun
Center for Drug Safety Evaluation and Research, Institute of Medical Biology, Chinese Academy of Medical Sciences &Peking Union Medical College, Kunming 650118, China.
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MA KailiMA Kaili
1. Center for Drug Safety Evaluation and Research, Institute of Medical Biology, Chinese Academy of Medical Sciences &Peking Union Medical College, Kunming 650118, China. 2. Medical Primate Research Center & Neuroscience Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005
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Affiliation:(1. Center for Drug Safety Evaluation and Research, Institute of Medical Biology, Chinese Academy of Medical Sciences &Peking Union Medical College, Kunming 650118, China. 2. Medical Primate Research Center & Neuroscience Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005)
Clc Number:R-33
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Abstract:

Parkinson’s disease (PD) is a common neurodegenerative disease. The main pathological marker,termed Lewy bodies (LBs), is a globular inclusion in the visible part of the substantia nigra pars compacta. The maincomponent of LBs is a partially hollow radial amyloid fiber, and the main component of the amyloid fiber is α-synuclein(AS). AS has a close association with the occurrence of PD and is a key protein in the study of PD pathogenesis. The ASfibrils have unique propagation characteristics and can induce a series of features similar to PD pathology, thus they can beused as a new material for efficient PD model establishment. This paper reviews the research progress of PD models based on AS fibrils.

Key words:Parkinson’s disease; α-synuclein; fibrils; disease model

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Received:April 17,2019
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Online: October 10,2019
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