Research progress in aging animal models

doi:10.3969/j. issn. 1671 -7856. 2019. 09. 017

Home > Archive>Volume 29, Issue 9, 2019 >109-113. DOI:10.3969/j. issn. 1671 -7856. 2019. 09. 017

Research progress in aging animal models
DOI:
                        10.3969/j. issn. 1671 -7856. 2019. 09. 017
                    
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                        LU YanhuaLU Yanhua
Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS); Comparative Medicine Center,Peking Union Medical College (PUMC); NHC Key Laboratory of Human Disease Comparative Medicine;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Beijing 100021, China
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GUAN BowenGUAN Bowen
Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS); Comparative Medicine Center,Peking Union Medical College (PUMC); NHC Key Laboratory of Human Disease Comparative Medicine;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Beijing 100021, China
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MENG AiminMENG Aimin
Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS); Comparative Medicine Center,Peking Union Medical College (PUMC); NHC Key Laboratory of Human Disease Comparative Medicine;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Beijing 100021, China
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Affiliation:(Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS); Comparative Medicine Center,Peking Union Medical College (PUMC); NHC Key Laboratory of Human Disease Comparative Medicine;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Beijing 100021, China)
Clc Number:R-33
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Abstract:

Aging is an inevitable outcome for all organisms. Researchers are exploring how to delay senescence andreduce the incidences of age-related diseases, prolong life-span and improve the quality of life in old age. Establishing aginganimal models that show aging phenotypes similar to those of humans is an effective way to explore the mechanisms ofhuman aging and research of anti-aging drugs. There are various animal models, such as nematodes, rodents and primates.In recent years, different types of genetically modified mice have emerged. At the same time, researchers have started touse animal models with different life-spans to conduct comparative studies. As aging is a complex biological process withmany influencing factors, only by conducting fully comparative medical research can we better transform the research results of aging and guarantee healthier aging of human beings.

Key words:aging; animal model; comparative medicine

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Received:February 18,2019
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Online: October 10,2019
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