Establishment of mouse models with a humanized immune system and applications for tumor immunotherapy

doi:10.3969/j. issn. 1671 -7856. 2019. 11. 015

Home > Archive>Volume 29, Issue 11, 2019 >98-104. DOI:10.3969/j. issn. 1671 -7856. 2019. 11. 015

Establishment of mouse models with a humanized immune system and applications for tumor immunotherapy
DOI:
                        10.3969/j. issn. 1671 -7856. 2019. 11. 015
                    
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Author:
                        GUO WenwenGUO Wenwen
1. Medical College of Yan’an University, Yan’an 716000, China.2. Laboratory Animal Center, the Air Force Medical University, Xi’an 710032
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QIAO Tianyun2QIAO Tianyun
Laboratory Animal Center, the Air Force Medical University, Xi’an 710032
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ZHANG Caiqin2ZHANG Caiqin
Laboratory Animal Center, the Air Force Medical University, Xi’an 710032
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ZHAO Jumei1ZHAO Jumei
Medical College of Yan’an University, Yan’an 716000, China.
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SHI Changhong2SHI Changhong
Laboratory Animal Center, the Air Force Medical University, Xi’an 710032
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Affiliation:(1. Medical College of Yan’an University, Yan’an 716000, China.2. Laboratory Animal Center, the Air Force Medical University, Xi’an 710032)
Clc Number:R-33
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Abstract:

The term “humanized mouse” refers to the use of a mouse model with human cells, tissues, or organs. Transplantation of human immune cells into immunodeficient mice is an established humanized mouse model of the immune system that effectively simulates characteristics of the human immune system. Indeed, it provides an ideal experimental tool for studying interactions between the immune system and tumors. In this article, we review the construction method , advantages, and disadvantages of different types of humanized mouse models of the immune system, and further illustrate their applications for tumor immunotherapy.

Key words:immune system; humanized mouse; immunodeficiency; tumor; immunotherapy

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