Advances in understanding the mechanism by which epoxyeicosatrienoic acids protect against ischemia / reperfusion injury through the mitochondrial pathway

doi:10.3969/j. issn. 1671 -7856. 2019. 11. 016

Home > Archive>Volume 29, Issue 11, 2019 >105-110. DOI:10.3969/j. issn. 1671 -7856. 2019. 11. 016

Advances in understanding the mechanism by which epoxyeicosatrienoic acids protect against ischemia / reperfusion injury through the mitochondrial pathway
DOI:
                        10.3969/j. issn. 1671 -7856. 2019. 11. 016
                    
CSTR:
                        [cstr]
                    
Author:
                        YE YongcaiYE Yongcai
1. Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, China.2. Guangdong Laboratory Animals Monitoring Institute; Guangdong Key Laboratory for Laboratory Animals,Guangzhou 510633
Find this author on All Journals
Find this author on BaiDu
Search for this author on this site
CHEN Zhexuan1CHEN Zhexuan
Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, China.
Find this author on All Journals
Find this author on BaiDu
Search for this author on this site
LI Xiang2LI Xiang
Guangdong Laboratory Animals Monitoring Institute; Guangdong Key Laboratory for Laboratory Animals,Guangzhou 510633
Find this author on All Journals
Find this author on BaiDu
Search for this author on this site
TAN Weijiang2TAN Weijiang
Guangdong Laboratory Animals Monitoring Institute; Guangdong Key Laboratory for Laboratory Animals,Guangzhou 510633
Find this author on All Journals
Find this author on BaiDu
Search for this author on this site
YANG Fenghua2YANG Fenghua
Guangdong Laboratory Animals Monitoring Institute; Guangdong Key Laboratory for Laboratory Animals,Guangzhou 510633
Find this author on All Journals
Find this author on BaiDu
Search for this author on this site
ZHANG Liangqing1ZHANG Liangqing
Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, China.
Find this author on All Journals
Find this author on BaiDu
Search for this author on this site

                    
Affiliation:(1. Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, China.2. Guangdong Laboratory Animals Monitoring Institute; Guangdong Key Laboratory for Laboratory Animals,Guangzhou 510633)
Clc Number:R-33
Fund Project:

Article

Figures

Metrics

Reference

Cited by

Materials

Comments

Abstract:

Increasing evidence suggests that epoxyeicosatrienoic acids (EETs) play a protective role in tissue and organ ischemia/ reperfusion ( I/ R) injury through a variety of mechanisms, and the mitochondrial pathway plays an important role in these mechanisms. However, as an important target for I/ R injury prevention and treatment, the mitochondrial pathway has not been explored in depth for EET-mediated protective mechanisms in I/ R injury. This review summarizes the role of mitochondrial K+ channels, mitochondrial permeability transition pores, mitochondrial proapoptotic proteins, and mitochondrial structural integrity in EET-mediated reductions of I/ R injury, providing a theoretical basis for further research. This is of great significance for preventing and treating I/ R injury of organs, and improving the prognosis of this disease.

Key words:epoxyeicosatrienoic acids(EETs); ischemia/ reperfusion(I/ R) injury; mitochondria

Get Citation

Copy

Article Metrics

Abstract:
PDF:
HTML:
Cited by:

History

Received:
Revised:
Adopted:
Online: December 10,2019
Published:

Home

About this journal

Editorial Board

Info for Author

Contact Us

中文版

Get Citation

Share

Article Metrics

History

Article QR Code