Research progress with non-rodent species in reproductive toxicity studies

doi:10.3969/j. issn. 1671 -7856. 2019. 11. 017

Home > Archive>Volume 29, Issue 11, 2019 >111-115. DOI:10.3969/j. issn. 1671 -7856. 2019. 11. 017

Research progress with non-rodent species in reproductive toxicity studies
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                        10.3969/j. issn. 1671 -7856. 2019. 11. 017
                    
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                        ZHANG Yuanhui1ZHANG Yuanhui
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100050, China.
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JIANG Jiandong2JIANG Jiandong
Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050
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KONG Weijia1KONG Weijia
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100050, China.
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Affiliation:(1. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100050, China. 2. Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050)
Clc Number:R-33
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Abstract:

With the observed decline in human fertility, reproductive toxicity research has become increasingly important. It is crucial to select appropriate animal models for evaluating the toxicity of compounds of interest. Because of similarities in their reproductive system, non-rodent animals are valuable models for researching reproductive health and disorders. In this review, we summarized the characteristics of non-rodent animal models and their current applications in reproductive toxicity studies. The aim of this study was to expand the range of animal models available for selection and to provide new approaches for nonclinical reproductive toxicity studies.

Key words:non-rodent; reproductive toxicity study; research status

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Online: December 10,2019
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