The role of Wip1 in cell homeostasis regulation

doi:10. 3969 / j.issn.1671-7856. 2020. 02. 022

Home > Archive>Volume 30, Issue 2, 2020 >141-146. DOI:10. 3969 / j.issn.1671-7856. 2020. 02. 022

The role of Wip1 in cell homeostasis regulation
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                        10. 3969 / j.issn.1671-7856. 2020. 02. 022
                    
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                        YAN FengYAN Feng
1.Cerebrovascular Diseases Research Institute, Xuan Wu Hospital, Capital Medical University, Beijing 100052, China. 2. Center for Brain Disorders Research, Capital Medical University, Beijing 100069. 3. Beijing Institute of Brain Disorders, Beijing 100069
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LUO Yumin1LUO Yumin
Cerebrovascular Diseases Research Institute, Xuan Wu Hospital, Capital Medical University, Beijing 100052, China
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ZHU Lingling4ZHU Lingling
Institute of Military Cognition and Brain Sciences, Academy of Military Medical Sciences, Beijing 100029
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FAN MingFAN Ming
2. Center for Brain Disorders Research, Capital Medical University, Beijing 100069. 3. Beijing Institute of Brain Disorders, Beijing 100069. 4. Institute of Military Cognition and Brain Sciences, Academy of Military Medical Sciences, Beijing 100029
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Affiliation:1.Cerebrovascular Diseases Research Institute, Xuan Wu Hospital, Capital Medical University, Beijing 100052, China. 2. Center for Brain Disorders Research, Capital Medical University, Beijing 100069. 3. Beijing Institute of Brain Disorders, Beijing 100069. 4. Institute of Military Cognition and Brain Sciences, Academy of Military Medical Sciences, Beijing 100029
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Abstract:

Wild-type p53 induced phosphatase 1 ( Wip1) is encoded by Ppm1d, a member of the protein phosphatase type 2C ( PP2C) phosphatase family and has an important role in several stress signaling pathways. Many previous studies have shown that Wip1 has a role in regulating transcription factors as well as being a p53 target. For example, Wip1 is crucial for cellular homeostasis by creating a negative feedback loop with p53, p38 / MAPK, and other factors. Thus, Wip1 plays a vital role in the regulation of the cell cycle and inhibiting apoptosis, DNA repair, and inflammation. In this review, we will discuss the function Wip1 related to these functions.

Key words:Wip1; cell homeostasis; apoptosis; cell cycle

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Received:June 05,2019
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Online: April 01,2020
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