Progress in the understanding of the roles and mechanisms of Traditional Chinese Medicine in lowering blood glucose by regulating gut microbiota

doi:10. 3969 / j.issn.1671-7856. 2020. 05. 019

Home > Archive>Volume 30, Issue 5, 2020 >120-126. DOI:10. 3969 / j.issn.1671-7856. 2020. 05. 019

Progress in the understanding of the roles and mechanisms of Traditional Chinese Medicine in lowering blood glucose by regulating gut microbiota
DOI:
                        10. 3969 / j.issn.1671-7856. 2020. 05. 019
                    
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Author:
                        TANG MingtianTANG Mingtian
1.Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Guangdong Institute of Applied Biological Resources, Guangzhou 510260,China. 2. Laboratory Animal Center of South-China Agricultural University, Guangzhou 510642
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XIAO Baiquan,1XIAO Baiquan,
Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Guangdong Institute of Applied Biological Resources, Guangzhou 510260,China
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LIU Zhonghua2LIU Zhonghua
Laboratory Animal Center of South-China Agricultural University, Guangzhou 510642
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RAO Junhua1RAO Junhua
Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Guangdong Institute of Applied Biological Resources, Guangzhou 510260,China
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Affiliation:1.Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Guangdong Institute of Applied Biological Resources, Guangzhou 510260,China. 2. Laboratory Animal Center of South-China Agricultural University, Guangzhou 510642
Clc Number:R-33
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Abstract:

Type 2 diabetes mellitus (T2DM) is a metabolic disease that seriously threatens the health of patients. Modern medicine is mainly used to control blood sugar stability and prevent T2DM complications. T2DM patients are required to take hypoglycemic agents for life. Although chemical drugs have a definite curative effect, they also cause several side effects after long-term use, which seriously limits their use. Traditional Chinese medicine (TCM) has a long history of blood glucose-lowering abilities, and it has unique advantages in the treatment of complex diseases ( i. e., T2DM), but its mechanism is not fully understood. Recent studies have shown that TCM can lower blood glucose by regulating gut microbiota to improve glucose metabolism, which provides new method and ideas for the prevention and treatment of T2DM. This article reviews the recent progress in the understanding of the roles and mechanisms of TCM, its extracts, and compound preparations to lower blood glucose by regulating gut microbiota. We also provide references and recommendations for future research on the blood glucose-lowering ability of TCM.

Key words:TCM; gut microbiota; blood glucose-lowering; role and mechanisms

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Received:October 28,2019
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Online: June 19,2020
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