The role of disease-associated microglia in the pathogenesis of Alzheimer’s disease

doi:10. 3969 / j.issn.1671-7856. 2020. 05. 021

Home > Archive>Volume 30, Issue 5, 2020 >132-136. DOI:10. 3969 / j.issn.1671-7856. 2020. 05. 021

The role of disease-associated microglia in the pathogenesis of Alzheimer’s disease
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                        10. 3969 / j.issn.1671-7856. 2020. 05. 021
                    
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                        CUI Yusha1CUI Yusha
2016 Undergraduate, Major in five-year Clinical Medicine, School of Basic Medical Science, Capital Medical University, Beijing 100069, China
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LU Xin2LU Xin
Morphological Laboratory of Experimental Teaching Center of Basic Medicine, School of Basic Medical Science, Capital Medical University, Beijing 100069
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LI Feng3LI Feng
Neurobiology Department, Beijing Institute for Brain Disorders; Beijing Center of Neural Regeneration and Repair, Capital Medical University, Beijing 100069
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Affiliation:1.2016 Undergraduate, Major in five-year Clinical Medicine, School of Basic Medical Science, Capital Medical University, Beijing 100069, China. 2. Morphological Laboratory of Experimental Teaching Center of Basic Medicine, School of Basic Medical Science, Capital Medical University, Beijing 100069. 3. Neurobiology Department, Beijing Institute for Brain Disorders; Beijing Center of Neural Regeneration and Repair, Capital Medical University, Beijing 100069
Clc Number:R-33
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Abstract:

Microglia, which are innate immune cells in the brain, play an irreplaceable role in the pathogenesis of Alzheimer’s disease. The M1 / M2 model has previously been used to explain the function of microglia. However, advances in technology, especially in cell transcriptome genomics, i. e., proteomics, have enabled a more comprehensive understanding of microglia. Disease-related microglia, one of the subtypes established from the perspective of the cell transcriptome, is of great significance for the construction of new subtypes of microglia. Indeed, this subtype may facilitate the prediction of many new AD risk sites in future research.

Key words:Alzheimer’s disease; microglia; disease-associated microglia

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Received:November 05,2019
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Online: June 19,2020
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