Tissue expression analysis of important pattern recognition receptors before and after ECTV infection in mice with different levels of resistance
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1.State Key Laboratory of Veterinary Etiological Biology / Key Laboratory of Veterninary Public Health of Ministry of Agriculture / Lanzhou Veterinary Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China. 2. College of Life Science and Engineering, Northwest University for Nationalities, Lanzhou 730030

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    Abstract:

    Objective To explore the relationship between disease resistance and susceptibility inmice expressing different levels of DNA pattern recognition receptors(PRRs). Methods The expression profiles of different DNA PPRs in BALB/ c and C57BL/ 6 mice infected with ECTV were detected using real-time fluorescent quantitative PCR ( qRT-PCR). Results TLR9, DAI, cGAS, RNA pol Ⅲ and RIG-Ⅰ were expressed in both mouse lines, but were expressed at significantly higher levels in the mousepox-resistant C57BL/ 6 mice compared with BALB/ c mice prior to infection. However, the expression of these genes increased noticeablyin the ECTV-susceptible BALB/ c mice after infection, with little change seen in C57BL/ 6 mice after infection. Conclusions Our findings suggest that these pathogen-specific PPRsmay be closely related to natural disease resistance in mice.

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History
  • Received:December 05,2019
  • Online: August 25,2020
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