Research progress on pigs as human disease models

doi:10. 3969 / j.issn.1671-7856. 2020. 07. 016

Home > Archive>Volume 30, Issue 7, 2020 >110-119. DOI:10. 3969 / j.issn.1671-7856. 2020. 07. 016

Research progress on pigs as human disease models
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                        10. 3969 / j.issn.1671-7856. 2020. 07. 016
                    
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                        CHEN YurongCHEN Yurong
1.National & Local Joint Engineering Laboratory for Animal Models of Human Diseases, First Hospital, Jilin University, Changchun 130021, China. 2. College of Veterinary Medicine, Jilin University, Changchun 130062
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AN Xinglan1AN Xinglan
National & Local Joint Engineering Laboratory for Animal Models of Human Diseases, First Hospital, Jilin University, Changchun 130021, China
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WANG Zhengzhu1WANG Zhengzhu
National & Local Joint Engineering Laboratory for Animal Models of Human Diseases, First Hospital, Jilin University, Changchun 130021, China
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ZHANG Sheng1ZHANG Sheng
National & Local Joint Engineering Laboratory for Animal Models of Human Diseases, First Hospital, Jilin University, Changchun 130021, China
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ZHAI Yanhui1ZHAI Yanhui
National & Local Joint Engineering Laboratory for Animal Models of Human Diseases, First Hospital, Jilin University, Changchun 130021, China
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DAI Xiangpeng1DAI Xiangpeng
National & Local Joint Engineering Laboratory for Animal Models of Human Diseases, First Hospital, Jilin University, Changchun 130021, China
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LI Ziyi1LI Ziyi
National & Local Joint Engineering Laboratory for Animal Models of Human Diseases, First Hospital, Jilin University, Changchun 130021, China
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Affiliation:1.National & Local Joint Engineering Laboratory for Animal Models of Human Diseases, First Hospital, Jilin University, Changchun 130021, China. 2. College of Veterinary Medicine, Jilin University, Changchun 130062
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Abstract:

Animal models of human disease have an important role in elucidating the pathogenesis of disease and exploring therapeutic method in basic medicine and pre-clinical research. Compared with rodents, there are many advantages to the use of pigs as animal models of disease because of their anatomy, physiology, nutrition metabolism, and for ethical reasons. A variety of human disease model pigs have been produced using method such as gene editing and somatic cell nuclear transfer. This paper reviews the research progress made on pig models in the fields of diabetes, cardiovascular disease, neurodegenerative disease, genetic disease, and tumors in recent years, and discusses the phenotypic instability of different models that could not accurately simulate human disease. We discuss important references for understanding and promoting the application of pigs as animal models of human disease.

Key words:animal model; human disease; pigs

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Received:December 26,2019
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Online: August 25,2020
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