Research progress on animal models of cardiac hypertrophy and compensation mechanisms

doi:10. 3969 / j.issn.1671-7856. 2020. 08. 016

Home > Archive>Volume 30, Issue 8, 2020 >102-106. DOI:10. 3969 / j.issn.1671-7856. 2020. 08. 016

Research progress on animal models of cardiac hypertrophy and compensation mechanisms
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                        10. 3969 / j.issn.1671-7856. 2020. 08. 016
                    
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                        LIU Mengdi1LIU Mengdi
Beijing Engineering Research Center for Experimental Animal Models of Human Diseases, Institute of Laboratory Animal Science, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100021, China
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ZHANG Lianfeng2ZHANG Lianfeng
Key Laboratory of Human Disease Comparative Medicine, National Health Commission of China (NHC), Institute of Laboratory Animal Science, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100021
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LYU Dan1LYU Dan
Beijing Engineering Research Center for Experimental Animal Models of Human Diseases, Institute of Laboratory Animal Science, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100021, China
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Affiliation:1.Beijing Engineering Research Center for Experimental Animal Models of Human Diseases, Institute of Laboratory Animal Science, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100021, China. 2. Key Laboratory of Human Disease Comparative Medicine, National Health Commission of China (NHC), Institute of Laboratory Animal Science, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100021
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Abstract:

Cardiac hypertrophy is a slow and effective compensatory function that mainly occurs under long-term stress loads. It is an adaptive response to changes in hemodynamics or myocardial injury. Decompensation of myocardial hypertrophy can eventually lead to an increased incidence of heart failure and sudden death, and no effective treatments have been established. In this paper, we summarize and compare the preparation method and characteristics of animal models of cardiac hypertrophy, including mice, rats, and large animals. We also summarize and compare the classical molecular signaling mechanisms of cardiac hypertrophy, including the mitotic protein kinase signaling pathway and the Ca²⁺ mediated signaling pathway, as well as the molecular mechanisms of decompensation induced by cardiac hypertrophy, including catecholamine and the cardiomyocyte apoptosis signaling pathway.

Key words:cardiac hypertrophy; animal model; mechanism

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Received:February 01,2020
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Online: September 02,2020
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