Mitochondrial autophagy and dysfunction in Parkinson’s disease

doi:10. 3969 / j.issn.1671-7856. 2020. 10. 018

Home > Archive>Volume 30, Issue 10, 2020 >121-127. DOI:10. 3969 / j.issn.1671-7856. 2020. 10. 018

Mitochondrial autophagy and dysfunction in Parkinson’s disease
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                        10. 3969 / j.issn.1671-7856. 2020. 10. 018
                    
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                        GAN XueGAN Xue
1.Institute of Primate Translational Medicine of Kunming University of Science and Technology, Kunming 650500, China. 2. Yunnan Province Key Laboratory of Primate Biomedicine, Kunming 650500
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LIU ShuyiLIU Shuyi
1.Institute of Primate Translational Medicine of Kunming University of Science and Technology, Kunming 650500, China. 2. Yunnan Province Key Laboratory of Primate Biomedicine, Kunming 650500
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WANG ZhengboWANG Zhengbo
1.Institute of Primate Translational Medicine of Kunming University of Science and Technology, Kunming 650500, China. 2. Yunnan Province Key Laboratory of Primate Biomedicine, Kunming 650500
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Affiliation:1.Institute of Primate Translational Medicine of Kunming University of Science and Technology, Kunming 650500, China. 2. Yunnan Province Key Laboratory of Primate Biomedicine, Kunming 650500
Clc Number:R-33
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Abstract:

Parkinson’ s disease ( PD) is the second most common central nervous system degenerative disease worldwide. One pathological feature is a-synuclein accumulation in the substantia nigra, and an early sign is mitochondrial dysfunction. The PD-related proteins PINK1, Parkin, DJ-1, and a-synuclein are involved in the process of mitochondrial autophagy and quality control. The mutation of PD-related proteins leads to abnormal autophagy and mitochondrial function. A failure of selective clearance of damaged mitochondria and mitochondrial dysfunction may eventually lead to dopaminergic neuron death. Therefore, the loss of control of PD-related proteins is closely related to PD occurrence. This article reviews the associations between mitochondrial autophagy, dysfunction, and Parkinson’s disease.

Key words:Parkinson’s disease; a-synuclein; mitochondrial autophagy; mitochondrial dysfunction

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Received:March 23,2020
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Online: November 25,2020
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