Applications of immunodeficient and humanized mice in stem cell quality control

doi:10. 3969 / j.issn.1671-7856. 2020. 10. 020

Home > Archive>Volume 30, Issue 10, 2020 >132-137. DOI:10. 3969 / j.issn.1671-7856. 2020. 10. 020

Applications of immunodeficient and humanized mice in stem cell quality control
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                        10. 3969 / j.issn.1671-7856. 2020. 10. 020
                    
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                        SHI GuiyingSHI Guiying
Institute of Laboratory Key Laboratory of Human Disease Sciences, Chinese Academy of Medical Sciences(CAMS); Comparative Medicine Center, Peking Union College(PUMC), Key Laboratory of Human Disease Comparative Medicine, National Health Commission of the People’s Republic of China; Key Laboratory of Human Disease Key Laboratory of Human Disease Models, State Administration of Traditional Chineses Medicine, Beijing 100021, China
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BAI LinBAI Lin
Institute of Laboratory Key Laboratory of Human Disease Sciences, Chinese Academy of Medical Sciences(CAMS); Comparative Medicine Center, Peking Union College(PUMC), Key Laboratory of Human Disease Comparative Medicine, National Health Commission of the People’s Republic of China; Key Laboratory of Human Disease Key Laboratory of Human Disease Models, State Administration of Traditional Chineses Medicine, Beijing 100021, China
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Affiliation:Institute of Laboratory Key Laboratory of Human Disease Sciences, Chinese Academy of Medical Sciences(CAMS); Comparative Medicine Center, Peking Union College(PUMC), Key Laboratory of Human Disease Comparative Medicine, National Health Commission of the People’s Republic of China; Key Laboratory of Human Disease Key Laboratory of Human Disease Models, State Administration of Traditional Chineses Medicine, Beijing 100021, China
Clc Number:R-33
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Abstract:

Stem cells self-renew, undergo multidirectional differentiation, and have great therapeutic potential for diabetes, brain injury, and acute myocardial infarction as examples. There are many types of stem cell products and many variations among batches. Therefore, quality control is particularly important for stem cell products before clinical use. Stem cells are immunogenic as living exogenous cells, and immunodeficient and humanized mice play an important role in stem cell quality control. Here, we review stem cell immunogenicities, summarize the commonly used immunodeficient and humanized mice, and outline the model applications of stem cell quality control to provide for a reference for stem cell quality control.

Key words:immunodeficient mice; humanized mice; stem cell; quality control

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Received:July 07,2020
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Online: November 25,2020
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