Establishment and application of animal models of venous bridge disease after coronary artery bypass grafting

doi:10. 3969 / j.issn.1671-7856. 2020. 12. 018

Home > Archive>Volume 30, Issue 12, 2020 >113-119. DOI:10. 3969 / j.issn.1671-7856. 2020. 12. 018

Establishment and application of animal models of venous bridge disease after coronary artery bypass grafting
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                        10. 3969 / j.issn.1671-7856. 2020. 12. 018
                    
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                        YANG Rencong1YANG Rencong
Department of Cardiovascular Surgery, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China
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YANG Fenghua2YANG Fenghua
Guangdong Provincial Key Laboratory for Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou 510633
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LI Xiaohui1LI Xiaohui
Department of Cardiovascular Surgery, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China
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LI Xiangnian1LI Xiangnian
Department of Cardiovascular Surgery, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China
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LI Wenhua1LI Wenhua
Department of Cardiovascular Surgery, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China
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LIAO Shengjie1LIAO Shengjie
Department of Cardiovascular Surgery, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China
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ZHANG Xiaoshen1ZHANG Xiaoshen
Department of Cardiovascular Surgery, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China
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Affiliation:1. Department of Cardiovascular Surgery, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China. 2. Guangdong Provincial Key Laboratory for Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou 510633
Clc Number:R-33
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Abstract:

Cardiovascular diseases constitute the largest burden to health worldwide. Ischemic heart disease seriously harms the physical and mental health of sufferers and its morbidity and mortality continue to increase. Coronary artery bypass grafting is a treatment for ischemic heart disease that can effectively rebuild the blood flow of the heart, but it has the problem of an insufficient long-term patency rate for venous grafts. Stable animal models can provide tools to investigate venous bypass graft diseases. This article summarizes the establishment and application of animal models of venous bypass graft disease to stimulate new ideas for research.

Key words:CABG; vein graft; restenosis; animal models; gene therapy

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Received:February 04,2020
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Online: February 10,2021
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