Pathological effects of annexin A2 investigated by gene regulation techniques

doi:10. 3969 / j.issn.1671-7856. 2021. 01. 019

Home > Archive>Volume 31, Issue 1, 2021 >125-131. DOI:10. 3969 / j.issn.1671-7856. 2021. 01. 019

Pathological effects of annexin A2 investigated by gene regulation techniques
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                        10. 3969 / j.issn.1671-7856. 2021. 01. 019
                    
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Author:
                        JIA Mengzhen1JIA Mengzhen
First School of Clinical Medicine, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China
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HUANG YanjieHUANG Yanjie
1.First School of Clinical Medicine, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China. 2. Department of Pediatrics, the First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450099
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YANG Xiaoqing2YANG Xiaoqing
Department of Pediatrics, the First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450099
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HAN Hongyan3HAN Hongyan
Henan University of Traditional Chinese Medicine, Zhengzhou 450046
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ZHANG Jianjiang4ZHANG Jianjiang
Department of Pediatrics, the First Affiliated Hospital Pediatrics of Zhengzhou University, Zhengzhou 450052
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Affiliation:1.First School of Clinical Medicine, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China. 2. Department of Pediatrics, the First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450099. 3. Henan University of Traditional Chinese Medicine, Zhengzhou 450046. 4. Department of Pediatrics, the First Affiliated Hospital Pediatrics of Zhengzhou University, Zhengzhou 450052
Clc Number:R-33
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Abstract:

Annexin A2 (ANXA2) is a multifunctional calcium-dependent phospholipid-binding protein. Previous rEPORts have shown that ANXA2 is closely related to the occurrence and development of various tumors. However, knockdown, knockout or overexpression of ANXA2 using gene regulation technologies have indicated that ANXA2 is multifunction and involved in various pathological processes including cells proliferation, tumor cell invasion, neoangiogenesis, the plasmin system, inflammatory response, epithelial - mesenchymal transition, anti-cancer drug resistance, and side effects. It also participates in the occurrence and development of tumors and non-tumor diseases. These pathological effects and pathways of ANXA2 at the genetic level were summarized on the basis of recent developments and we also explored whether ANXA2 can be used as a target for eaR_Ly diagnosis and treatment of the related diseases.

Key words:ANXA2; gene regulation; pathological effects

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Received:June 08,2020
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Online: March 02,2021
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