In China, the incidence of gastric cancer has increased with the aging population, and this is a malignant cancer with high mortality. Currently, the lack of effective anti-tumor drugs is a key concern; therefore, preclinical research is crucial, and animal models are important. Modern research emphasizes precise tumor treatment, and patient-derived xenografts ( PDX) have emerged from related research. PDX are highly consistent with the biological characteristics of the original tumor, which addresses the deficiencies of the traditional cell line model and provides a new platform for tumor research. In this paper, we review the established method of PDX modelling for gastric cancer. We also summarize the related research and its application in recent years.