Research progress on the molecular mechanisms of long non-coding RNA regulating cellular autophagy and nervous system diseases

doi:10. 3969 / j.issn.1671-7856. 2021. 03. 017

Home > Archive>Volume 31, Issue 3, 2021 >111-116,122. DOI:10. 3969 / j.issn.1671-7856. 2021. 03. 017

Research progress on the molecular mechanisms of long non-coding RNA regulating cellular autophagy and nervous system diseases
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                        10. 3969 / j.issn.1671-7856. 2021. 03. 017
                    
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Author:
                        LI FajingLI Fajing
School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China
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CHEN PengCHEN Peng
School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China
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YANG RenhuaYANG Renhua
School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China
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CHEN DeyunCHEN Deyun
School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China
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YANG YuanYANG Yuan
School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China
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HE BoHE Bo
School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China
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SHEN ZhiqiangSHEN Zhiqiang
School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China
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Affiliation:School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China
Clc Number:R-33
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Abstract:

Long non-coding RNA ( lncRNA) is RNA that is >200 bp long and regulates gene expression at the transcriptional, post-transcriptional and translational levels. Dysfunction of lncRNA is closely related to the pathological processes of many diseases, including nervous system diseases. Autophagy is a lysosome-dependent degradation pathway in eukaryotic cells that plays an important role in cell growth, development, senescence and maintenance of intracellular homeostasis. Recent studies have confirmed that lncRNA plays an important role in the occurrence and development of nervous system diseases, and regulation of autophagy by lncRNA is an important topic; however, the specific mechanisms of this regulation remain unclear. This paper reviews the molecular mechanisms of lncRNA regulation in autophagy and its related research progress concerning nervous system diseases to provide a theoretical and experimental basis for further studying the pathogenesis and drug treatment strategies of nervous system diseases.

Key words:long non-coding RNA; autophagy; nervous system diseases; miRNA

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Received:July 24,2020
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Online: April 30,2021
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