Research on animal model of depression induced by chronic unpredictable mild stress based on literature database

doi:10. 3969 / j.issn.1671-7856. 2021. 04. 012

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Research on animal model of depression induced by chronic unpredictable mild stress based on literature database
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                        10. 3969 / j.issn.1671-7856. 2021. 04. 012
                    
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Author:
                        LI ShanshanLI Shanshan
1.Affiliated TCM Hospital, Sino-Portugal TCM International Cooperation Center/ School of Pharmacy, Southwest Medical University, Luzhou 646000, China. 2.Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193.
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LIU XinminLIU Xinmin
1.Affiliated TCM Hospital, Sino-Portugal TCM International Cooperation Center/ School of Pharmacy, Southwest Medical University, Luzhou 646000, China. 2.Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193.
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WANG QiongWANG Qiong
1.Affiliated TCM Hospital, Sino-Portugal TCM International Cooperation Center/ School of Pharmacy, Southwest Medical University, Luzhou 646000, China.3.Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193
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Affiliation:1.Affiliated TCM Hospital, Sino-Portugal TCM International Cooperation Center/ School of Pharmacy, Southwest Medical University, Luzhou 646000, China. 2.Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193. 3.Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193
Clc Number:R-33
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Abstract:

Objective To summarize popular stimulation factors, model duration, and main behavioral tests used in the chronic unpredicted mild stress (CUMS) model of depression, so as to provide a reference for the use of CUMS in depression research. Methods Literature related to CUMS models from the past 10 years was searched for in PubMed databases and screened according to certain criteria. The animals, stressors, and duration of CUMS models were summarized. Results Male rats are most often used in CUMS models. Seven to nine stressors should be chosen for an experiment and should not be repeated within 3-7 days. Among the stimulation factors, deprivation of food or water, damp bedding, cold water swimming, tilt cages, and changes in light rhythm are recommended. Three to four weeks are recommended for the model duration. Behavioral tests included sucrose preference test, open field test and force swimming test. Conclusions This study provides a useful reference for the use of CUMS in models of depression regarding the animals, stimulation factors, and model duration.

Key words:chronic unpredicted mild stress; depression; rat; mice; stimulation factors

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Received:July 01,2020
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Online: May 28,2021
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