The mechanism of TLR4 / NF-κB in atherosclerosis

doi:10. 3969 / j.issn.1671-7856. 2021. 04. 020

Home > Archive>Volume 31, Issue 4, 2021 >137-142. DOI:10. 3969 / j.issn.1671-7856. 2021. 04. 020

The mechanism of TLR4 / NF-κB in atherosclerosis
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                        10. 3969 / j.issn.1671-7856. 2021. 04. 020
                    
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                        LI Jiahui1LI Jiahui
Department of Immunology, Basic Medical College of Guangxi Medical University, Nanning 530000, China
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WANG Xinpei3WANG Xinpei
Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing 100021
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LENG JingLENG Jing
1.Department of Immunology, Basic Medical College of Guangxi Medical University, Nanning 530000, China. 2.Guangxi University of Chinese Medicine, Guangxi Key Laboratory of Translational Medicine for Treating High-Incidence Infectious Diseases with Integrative Medicine, Nanning 530200.
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Affiliation:1.Department of Immunology, Basic Medical College of Guangxi Medical University, Nanning 530000, China. 2.Guangxi University of Chinese Medicine, Guangxi Key Laboratory of Translational Medicine for Treating High-Incidence Infectious Diseases with Integrative Medicine, Nanning 530200. 3.Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing 100021
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Abstract:

Atherosclerosis (AS) is a chronic disease characterized by lipid deposits in blood vessels. An increasing number of studies suggest that immune-mediated inflammatory responses play an important role in the pathogenesis of AS. Toll-like receptor 4 (TLR4) participates in various stages of AS as a member of the natural immune pattern recognition receptor family, and thus has become an important target for the treatment of AS. This article reviews the progress in research regarding TLR4 and AS.

Key words:toll-like receptor4(TLR4); NF-κB; inflammation

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Received:November 09,2020
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Online: May 28,2021
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