Research progress of long non-coding RNA involvement in angiogenesis

doi:10. 3969 / j.issn.1671-7856. 2021. 04. 021

Home > Archive>Volume 31, Issue 4, 2021 >143-149. DOI:10. 3969 / j.issn.1671-7856. 2021. 04. 021

Research progress of long non-coding RNA involvement in angiogenesis
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                        10. 3969 / j.issn.1671-7856. 2021. 04. 021
                    
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                        WANG Liran1WANG Liran
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
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YANG LihongYANG Lihong
1.First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China.3.National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381
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NING Wenhua1NING Wenhua
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
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QIN Yinan1QIN Yinan
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
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LI JingLI Jing
2.Institute of Acupuncture and Moxibustion, the First Teaching Hospital of Tianjin University of TCM, Tianjin 300381. 3.National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381
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DU YuanhaoDU Yuanhao
1.First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China.3.National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381
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Affiliation:1.First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China. 2.Institute of Acupuncture and Moxibustion, the First Teaching Hospital of Tianjin University of TCM, Tianjin 300381. 3.National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381
Clc Number:R-33
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Abstract:

Angiogenesis is closely related to many diseases and plays an important role in the development and prognosis of diseases. Long non-coding RNAs ( lncRNAs) are important regulatory molecules of angiogenesis that are involved in the pathological recovery process of ischemic stroke, tumor, atherosclerosis and other diseases by regulating the phenotypic transformation of vascular endothelial cells, angiogenic factors and miRNA expression. Here, we review the biological functions of lncRNAs, and describe their expression and regulatory effects in angiogenesis and vascular diseases to provide reference for ongoing research into lncRNA mechanisms of action and their clinical application in angiogenesis.

Key words:lncRNA; angiogenesis; EC; VEGF; miRNA; signaling pathways

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Received:July 22,2020
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Online: May 28,2021
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