+Advanced Search
Home > Archive>Volume 31, Issue 5, 2021 >36-40. DOI:10. 3969 / j.issn.1671-7856. 2021. 05. 006
PDF HTML XML Export Cite reminder
Effect of Naoshuantong capsule on the expression of aortic inflammatory factors in ApoE- / -mice
CSTR:
[cstr]
Author:
Affiliation:

1.Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education,Zunyi Medical University,Zunyi, Guizhou 563006, China. 2. Experimental Animal Center, Xuanwu Hospital of Capital Medical University, Beijing Municipal Geriatrics Medical Reseach Center, Beijing 100053

Clc Number:

R-33

  • Article
    • | |
  • Metrics
    • |
  • Reference
    • |
  • Related
    • |
  • Cited by
    • | |
  • Comments
    Abstract:

    Objective To investigate the effects of Naoshuantong capsule on the expression of inflammatory cytokines IL-1β, IL-6, ICAM-1, MMP-9 and TNF-α in the atherosclerosis ApoE-/-mouse model and to explore therapeutic mechanisms. Methods Eight-week-old ApoE-/- male mice were fed a high-fat diet to establish atherosclerosis. After the diet, the mice were randomly divided into the atherosclerosis control group, Naoshuantong capsule low-dose group and Naoshuantong capsule high-dose group. The low-dose and high-dose groups were given 0. 5 and 1. 0 g / kg Naoshuantong capsule, respectively, and the control group was given an equivalent volume of distilled water. After 12 weeks, whole-aortic intimal plaques were detected by oil red O staining, and protein levels of inflammation-related factors IL-1β, IL-6, ICAM- 1, MMP-9 and TNF-α were observed and compared between each group. Results After drug intervention, the aortic plaque area of the high-dose group was significantly lower than that of the control group (P< 0. 01). Compared with the atherosclerosis control group, protein expression levels of IL-1β and IL-6 were decreased in the low-dose group ( P< 0. 05), and IL-1β, IL-6, ICAM-1 and TNF-α levels were markedly reduced in the high-dose group (P<0. 05,P<0. 01). The expression of MMP-9 was not significantly different compared with the control group ( P> 0.05). Conclusions Naoshuantong capsule regulated the expression of inflammatory-related factors, and its potential mechanism for the treatment of atherosclerosis may be related to inflammatory-related pathways.

    Reference
    Related
    Cited by
Get Citation

Copy
Share
Article Metrics
  • Abstract:
  • PDF:
  • HTML:
  • Cited by:
History
  • Received:September 01,2020
  • Online: June 25,2021
Article QR Code
You are the first Visitors
® 2025 All Rights Reserved
Address：5 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China Postcode： Phone：86-10-67779337 E-mail:bjb@cnilas.org
Supported by:Beijing E-Tiller Technology Development Co., Ltd.