Research progress of the hollow fiber tumor model

doi:10. 3969 / j.issn.1671-7856. 2021. 05. 023

Home > Archive>Volume 31, Issue 5, 2021 >139-145. DOI:10. 3969 / j.issn.1671-7856. 2021. 05. 023

Research progress of the hollow fiber tumor model
DOI:
                        10. 3969 / j.issn.1671-7856. 2021. 05. 023
                    
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Author:
                        WANG Xuejing1WANG Xuejing
Center of Integrated Traditional Chinese and Western Medicine, Beijing You ′an Hospital, Capital Medical University, Beijing 100069, China
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YIN Ling1YIN Ling
Center of Integrated Traditional Chinese and Western Medicine, Beijing You ′an Hospital, Capital Medical University, Beijing 100069, China
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KOU Buxin2KOU Buxin
Institute of Liver Disease, Beijing You ′an Hospital, Capital Medical University, Beijing 100069
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CHAI Mengyin2CHAI Mengyin
Institute of Liver Disease, Beijing You ′an Hospital, Capital Medical University, Beijing 100069
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CHEN Dexi2CHEN Dexi
Institute of Liver Disease, Beijing You ′an Hospital, Capital Medical University, Beijing 100069
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LIU Xiaoni2LIU Xiaoni
Institute of Liver Disease, Beijing You ′an Hospital, Capital Medical University, Beijing 100069
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WANG Xiaojun1WANG Xiaojun
Center of Integrated Traditional Chinese and Western Medicine, Beijing You ′an Hospital, Capital Medical University, Beijing 100069, China
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Affiliation:1.Center of Integrated Traditional Chinese and Western Medicine, Beijing You ′an Hospital, Capital Medical University, Beijing 100069, China. 2. Institute of Liver Disease, Beijing You ′an Hospital, Capital Medical University, Beijing 100069
Clc Number:R-33
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Abstract:

The hollow fiber tumor model, also known as the hollow fiber assay (HFA), was designed by the US National Cancer Institute for the purpose of evaluating preliminary in vivo drug efficacy in a simple, rapid manner. In recent years, it has been widely used in the research and development of anti-tumor drugs, from which new and improved optimizations and applications have emerged. This paper systematically summarizes the characteristics and advantages of the HFA in anti-tumor drug screening, together with the last 10 years of progress in HFA applications. We anticipate that the HFA will play an increasingly important role in anti-tumor drug research, and the improved model of HFA will have broad applications in research on individualized cancer treatments and mechanistic studies.

Key words:hollow fiber assay; anti-tumor; drug screening; application value; in vivo

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Received:July 24,2020
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Online: June 25,2021
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