Progress in research on the role of chemokines and microglia in the neuroinflammation of Alzheimer’s disease
CSTR:
Author:
Affiliation:

1.Hebei Key Lab of Laboratory Animal Science, Hebei Medical University, Shijiazhuang 050017, China. 2. Key Laboratory of Human Disease Comparative Medicine, National Health and Family Planning Commission of P. R. C, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Comparative Medicine Center, Peking Union Medical College, Beijing 100021

Clc Number:

R-33

  • Article
  • | |
  • Metrics
  • |
  • Reference
  • |
  • Related
  • |
  • Cited by
  • | |
  • Comments
    Abstract:

    Alzheimer’ s disease ( AD) is a chronic progressive neurodegenerative disease characterized by dementia as the main symptom. The main neuropathologic features include senile plaques, neurofibrillary tangles, neuroinflammation, and neuron loss. Deposition of amyloid β-protein and misfolded tau protein in patients with AD induces the activation of microglia; this leads to the secretion of cytokines and chemokines, which jointly induce a neuroinflammatory response and affect the progression of AD. This review briefly summarizes the role of microglial activation and chemokine release in the neuroinflammation of AD and provides new insight into the treatment of AD.

    Reference
    Related
    Cited by
Get Citation
Share
Article Metrics
  • Abstract:
  • PDF:
  • HTML:
  • Cited by:
History
  • Received:August 06,2020
  • Online: August 03,2021
Article QR Code